4DQG
Crystal Structure of apo(G16C/L38C) HIV-1 Protease
Summary for 4DQG
Entry DOI | 10.2210/pdb4dqg/pdb |
Related | 4DQB 4DQC 4DQE 4DQF 4DQH |
Descriptor | Aspartyl protease, N-HYDROXYGUANIDINE, GLYCEROL, ... (7 entities in total) |
Functional Keywords | hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 (HIV-1) |
Total number of polymer chains | 2 |
Total formula weight | 22144.92 |
Authors | Schiffer, C.A.,Mittal, S. (deposition date: 2012-02-15, release date: 2012-03-07, Last modification date: 2017-11-15) |
Primary citation | Mittal, S.,Cai, Y.,Nalam, M.N.,Bolon, D.N.,Schiffer, C.A. Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134:4163-4168, 2012 Cited by PubMed: 22295904DOI: 10.1021/ja2095766 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79 Å) |
Structure validation
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