4DQG

Crystal Structure of apo(G16C/L38C) HIV-1 Protease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE HGU A 101

Chain	Residue
A	ARG14
A	ILE15
A	CYS16
A	GLY17
A	ILE63
B	ARG14

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 102

Chain	Residue
A	ASP25
A	GOL103
B	ASP25

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 103

Chain	Residue
A	ALA28
A	ASP29
A	ASP30
A	GLY48
A	GOL102

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE OXY A 104

Chain	Residue
A	CYS38

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 101

Chain	Residue
B	ASP29
B	ASP30
B	GLY48

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site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT B 102

Chain	Residue
B	PRO1
B	ARG57
B	HIS69

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site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PO4 B 103

Chain	Residue
B	LYS7
B	ARG8

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI

Chain	Residue	Details
A	ALA22-ILE33

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	138
Details	Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	20
Details	Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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