4DQH

Crystal Structure of (R14C/E65C) HIV-1 Protease in complex with DRV

Summary for 4DQH

Entry DOI	10.2210/pdb4dqh/pdb
Related	4DQB 4DQC 4DQE 4DQF 4DQG
Descriptor	Wild-type HIV-1 protease dimer, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, GLYCEROL, ... (4 entities in total)
Functional Keywords	hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1 (HIV-1)
Total number of polymer chains	2
Total formula weight	22015.12
Authors	Schiffer, C.A.,Mittal, S. (deposition date: 2012-02-15, release date: 2012-03-07, Last modification date: 2024-02-28)
Primary citation	Mittal, S.,Cai, Y.,Nalam, M.N.,Bolon, D.N.,Schiffer, C.A. Hydrophobic core flexibility modulates enzyme activity in HIV-1 protease. J.Am.Chem.Soc., 134:4163-4168, 2012 Cited by PubMed: 22295904 DOI: 10.1021/ja2095766 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation