8IA3
 
 | | Crystal structure of human USF2 bHLHLZ domain in complex with DNA | | Descriptor: | DNA (5'-D(*GP*CP*GP*CP*GP*TP*CP*AP*CP*GP*TP*GP*CP*CP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*AP*CP*GP*GP*GP*CP*AP*CP*GP*TP*GP*AP*CP*GP*CP*GP*C)-3'), Upstream stimulatory factor 2 | | Authors: | Huang, C, Fang, P, Wang, J. | | Deposit date: | 2023-02-07 | | Release date: | 2023-09-20 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Tetramerization of upstream stimulating factor USF2 requires the elongated bent leucine zipper of the bHLH-LZ domain.
J.Biol.Chem., 299, 2023
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8IBW
 | | Structure of R2 with 3'UTR and DNA in binding state | | Descriptor: | 3'UTR, DNA (60-MER), Reverse transcriptase-like protein, ... | | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | | Deposit date: | 2023-02-10 | | Release date: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
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8IBZ
 | | Structure of R2 with 5'ORF and 3'UTR | | Descriptor: | 5ORF-linker-3UTR, Reverse transcriptase-like protein, ZINC ION | | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | | Deposit date: | 2023-02-10 | | Release date: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
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8IBY
 | | Structure of R2 with 5'ORF | | Descriptor: | 5'ORF RNA, Reverse transcriptase-like protein, ZINC ION | | Authors: | Deng, P, Tan, S, Wang, J, Liu, J.J. | | Deposit date: | 2023-02-10 | | Release date: | 2023-09-20 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Structural RNA components supervise the sequential DNA cleavage in R2 retrotransposon.
Cell, 186, 2023
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4R7L
 | | Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 | | Descriptor: | ACETATE ION, GLYCEROL, IMIDAZOLE, ... | | Authors: | Ouyang, P, Cui, K, Lu, W, Huang, J. | | Deposit date: | 2014-08-27 | | Release date: | 2015-11-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | Human Leukotriene A4 Hydrolase in complex with SAHA
To be Published
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8EU3
 | | Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ... | | Authors: | Hu, Z, Zheng, X, Yang, J. | | Deposit date: | 2022-10-18 | | Release date: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (3.62 Å) | | Cite: | Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel.
Nat Commun, 14, 2023
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8ETP
 | | Cryo-EM structure of cGMP bound closed state of human CNGA3/CNGB3 channel in GDN | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ... | | Authors: | Hu, Z, Zheng, X, Yang, J. | | Deposit date: | 2022-10-17 | | Release date: | 2023-08-02 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel.
Nat Commun, 14, 2023
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4NT9
 | | Crystal structure of an L,D-carboxypeptidase DacB from Streptococcus pneumonia | | Descriptor: | ACETATE ION, GLYCEROL, Putative uncharacterized protein, ... | | Authors: | Yang, Y.H, Zhang, J, Jiang, Y.L, Zhou, C.Z, Chen, Y. | | Deposit date: | 2013-12-02 | | Release date: | 2014-11-12 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.705 Å) | | Cite: | Crystal structure of an L,D-carboxypeptidase DacB from Streptococcus pneumonia
To be Published
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8EV9
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8EVC
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8EV8
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6YG6
 | | Crystal structure of MKK7 (MAP2K7) covalently bound with type-II inhibitor TL10-105 | | Descriptor: | 1,2-ETHANEDIOL, Dual specificity mitogen-activated protein kinase kinase 7, ~{N}-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-[[(3~{S})-1-propanoylpyrrolidin-3-yl]amino]pyrimidin-4-yl]oxy-benzamide | | Authors: | Chaikuad, A, Tan, L, Wang, J, Liang, Y, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2020-03-27 | | Release date: | 2020-08-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities.
Cell Chem Biol, 27, 2020
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8FHD
 | | Cryo-EM structure of human voltage-gated sodium channel Nav1.6 | | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | Authors: | Fan, X, Huang, J, Yan, N. | | Deposit date: | 2022-12-14 | | Release date: | 2023-02-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structure of human voltage-gated sodium channel Na v 1.6.
Proc.Natl.Acad.Sci.USA, 120, 2023
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5Z2S
 | | Crystal structure of DUX4-HD2 domain | | Descriptor: | Double homeobox protein 4 | | Authors: | Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G. | | Deposit date: | 2018-01-03 | | Release date: | 2018-04-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural basis of DUX4/IGH-driven transactivation.
Leukemia, 32, 2018
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5ZCS
 | | 4.9 Angstrom Cryo-EM structure of human mTOR complex 2 | | Descriptor: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | | Authors: | Chen, X, Liu, M, Tian, Y, Wang, H, Wang, J, Xu, Y. | | Deposit date: | 2018-02-20 | | Release date: | 2018-03-21 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Cryo-EM structure of human mTOR complex 2.
Cell Res., 28, 2018
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7WKC
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3T9N
 | | Crystal structure of a membrane protein | | Descriptor: | DODECYL-BETA-D-MALTOSIDE, Small-conductance mechanosensitive channel | | Authors: | Yang, M, Zhang, X, Ge, J, Wang, J. | | Deposit date: | 2011-08-03 | | Release date: | 2012-10-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.456 Å) | | Cite: | Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance
Proc.Natl.Acad.Sci.USA, 109, 2012
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8D4P
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8J4I
 | | Unveiling the Role of Human Prohibitin 2 as a Mitochondrial Calcium Channel in Parkinson's Disease | | Descriptor: | Prohibitin-2 | | Authors: | Li, Y.Y, Fang, Y, Gao, Y.X, Ding, W, Yang, J, Liu, Y, Shen, B, Wang, J.F, Zhou, S. | | Deposit date: | 2023-04-20 | | Release date: | 2024-06-05 | | Method: | SOLUTION NMR | | Cite: | Human Prohibitin 2 is a Mitochondrial Ca2+-Selective Channel
To Be Published
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4RSY
 | | Crystal structures of the Human leukotriene A4 Hydrolase complex with a potential inhibitor H7 | | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ACETIC ACID, IMIDAZOLE, ... | | Authors: | Ouyang, P, Lu, W, Cui, K, Huang, J. | | Deposit date: | 2014-11-12 | | Release date: | 2015-12-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1
To be Published
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4RVB
 | | Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase | | Descriptor: | ACETATE ION, ACETIC ACID, GLYCEROL, ... | | Authors: | Ouyang, P, Lu, W, Cui, K, Huang, J. | | Deposit date: | 2014-11-25 | | Release date: | 2015-12-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase
To be Published
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4U7N
 | | Inactive structure of histidine kinase | | Descriptor: | Histidine protein kinase sensor protein | | Authors: | Cai, Y, Hu, X, Sang, J. | | Deposit date: | 2014-07-31 | | Release date: | 2015-09-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Conformational dynamics of the essential sensor histidine kinase WalK.
Acta Crystallogr D Struct Biol, 73, 2017
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8EUC
 | | Cryo-EM structure of cGMP bound human CNGA3/CNGB3 channel in GDN, transition state 2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel alpha-3, ... | | Authors: | Hu, Z, Zheng, X, Yang, J. | | Deposit date: | 2022-10-18 | | Release date: | 2023-08-09 | | Method: | ELECTRON MICROSCOPY (3.61 Å) | | Cite: | Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel.
Nat Commun, 14, 2023
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8EVA
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8EVB
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