7ND1
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![BU of 7nd1 by Molmil](/molmil-images/mine/7nd1) | First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain | Descriptor: | 3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, ... | Authors: | Cierpicki, T, Lund, G, Jaremko, L. | Deposit date: | 2021-01-29 | Release date: | 2021-06-16 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat.Chem.Biol., 17, 2021
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6WI7
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![BU of 6wi7 by Molmil](/molmil-images/mine/6wi7) | RING1B-BMI1 fusion in closed conformation | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1 chimera, ... | Authors: | Cho, H.J, Cierpicki, T. | Deposit date: | 2020-04-08 | Release date: | 2021-04-14 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.702 Å) | Cite: | Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat.Chem.Biol., 17, 2021
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6WI8
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![BU of 6wi8 by Molmil](/molmil-images/mine/6wi8) | |
2KKF
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![BU of 2kkf by Molmil](/molmil-images/mine/2kkf) | Solution structure of MLL CXXC domain in complex with palindromic CPG DNA | Descriptor: | 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3', Histone-lysine N-methyltransferase HRX, ZINC ION | Authors: | Cierpicki, T, Riesbeck, J.E, Grembecka, J.E, Lukasik, S.M, Popovic, R, Omonkowska, M, Shultis, D.S, Zeleznik-Le, N.J, Bushweller, J.H. | Deposit date: | 2009-06-18 | Release date: | 2009-12-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. Nat.Struct.Mol.Biol., 17, 2010
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3KQZ
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![BU of 3kqz by Molmil](/molmil-images/mine/3kqz) | Structure of a protease 2 | Descriptor: | CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ... | Authors: | McGowan, S, Whisstock, J.C. | Deposit date: | 2009-11-17 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3KQX
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![BU of 3kqx by Molmil](/molmil-images/mine/3kqx) | Structure of a protease 1 | Descriptor: | CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ... | Authors: | McGowan, S, Whisstock, J.C. | Deposit date: | 2009-11-17 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3KR4
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![BU of 3kr4 by Molmil](/molmil-images/mine/3kr4) | Structure of a protease 3 | Descriptor: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, CARBONATE ION, M17 leucyl aminopeptidase, ... | Authors: | McGowan, S, Whisstock, J.C. | Deposit date: | 2009-11-17 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3KR5
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![BU of 3kr5 by Molmil](/molmil-images/mine/3kr5) | Structure of a protease 4 | Descriptor: | (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, CARBONATE ION, M17 leucyl aminopeptidase, ... | Authors: | McGowan, S, Whisstock, J.C. | Deposit date: | 2009-11-17 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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1D4U
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![BU of 1d4u by Molmil](/molmil-images/mine/1d4u) | INTERACTIONS OF HUMAN NUCLEOTIDE EXCISION REPAIR PROTEIN XPA WITH RPA70 AND DNA: CHEMICAL SHIFT MAPPING AND 15N NMR RELAXATION STUDIES | Descriptor: | NUCLEOTIDE EXCISION REPAIR PROTEIN XPA (XPA-MBD), ZINC ION | Authors: | Buchko, G.W, Daughdrill, G.W, de Lorimier, R, Rao, S, Isern, N.G, Lingbeck, J, Taylor, J, Wold, M.S, Gochin, M, Spicer, L.D, Lowry, D.F, Kennedy, M.A. | Deposit date: | 1999-10-06 | Release date: | 1999-10-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. Biochemistry, 38, 1999
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3EBH
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![BU of 3ebh by Molmil](/molmil-images/mine/3ebh) | Structure of the M1 Alanylaminopeptidase from malaria complexed with bestatin | Descriptor: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, GLYCEROL, M1 family aminopeptidase, ... | Authors: | McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C. | Deposit date: | 2008-08-27 | Release date: | 2009-01-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase Proc.Natl.Acad.Sci.USA, 106, 2009
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1K5D
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![BU of 1k5d by Molmil](/molmil-images/mine/1k5d) | Crystal structure of Ran-GPPNHP-RanBP1-RanGAP complex | Descriptor: | GTP-binding nuclear protein RAN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R. | Deposit date: | 2001-10-10 | Release date: | 2002-02-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | RanGAP mediates GTP hydrolysis without an arginine finger. Nature, 415, 2002
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4R0L
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![BU of 4r0l by Molmil](/molmil-images/mine/4r0l) | Anti-canine CD28 antibody, 1C6, bound canine CD28 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gewe, M.M, Strong, R.K. | Deposit date: | 2014-07-31 | Release date: | 2015-07-08 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Anti-CD28 Antibody-Initiated Cytokine Storm in Canines. Transplant Direct, 1, 2015
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1K5G
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![BU of 1k5g by Molmil](/molmil-images/mine/1k5g) | Crystal structure of Ran-GDP-AlFx-RanBP1-RanGAP complex | Descriptor: | ALUMINUM FLUORIDE, GTP-binding nuclear protein RAN, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Seewald, M.J, Koerner, C, Wittinghofer, A, Vetter, I.R. | Deposit date: | 2001-10-10 | Release date: | 2002-02-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | RanGAP mediates GTP hydrolysis without an arginine finger. Nature, 415, 2002
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5VNB
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![BU of 5vnb by Molmil](/molmil-images/mine/5vnb) | YEATS in complex with histone H3 | Descriptor: | 1,2-ETHANEDIOL, H3K23acK27ac peptide, SULFATE ION, ... | Authors: | Cho, H.J, Cierpicki, T. | Deposit date: | 2017-04-29 | Release date: | 2018-09-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode. ACS Chem. Biol., 13, 2018
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3EBI
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![BU of 3ebi by Molmil](/molmil-images/mine/3ebi) | Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog | Descriptor: | (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, GLYCEROL, M1 family aminopeptidase, ... | Authors: | McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C. | Deposit date: | 2008-08-27 | Release date: | 2009-01-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase Proc.Natl.Acad.Sci.USA, 106, 2009
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3EBG
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![BU of 3ebg by Molmil](/molmil-images/mine/3ebg) | Structure of the M1 Alanylaminopeptidase from malaria | Descriptor: | GLYCEROL, M1 family aminopeptidase, MAGNESIUM ION, ... | Authors: | McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C. | Deposit date: | 2008-08-27 | Release date: | 2009-01-27 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase Proc.Natl.Acad.Sci.USA, 106, 2009
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2JYI
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![BU of 2jyi by Molmil](/molmil-images/mine/2jyi) | Solution structure of MLL CXXC domain | Descriptor: | ZINC ION, Zinc finger protein HRX | Authors: | Cierpicki, T, Bushweller, J.H. | Deposit date: | 2007-12-13 | Release date: | 2008-12-09 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structural basis for maintenance of unmethylated CpG elements by the CXXC domain of MLL and its critical contributions to MLL-AF9 immortalization activity To be Published
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2MTN
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![BU of 2mtn by Molmil](/molmil-images/mine/2mtn) | Solution structure of MLL-IBD complex | Descriptor: | Histone-lysine N-methyltransferase 2A, PC4 and SFRS1-interacting protein fusion | Authors: | Cierpicki, T, Pollock, J, Murai, M. | Deposit date: | 2014-08-23 | Release date: | 2014-12-03 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV. Blood, 124, 2014
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3HXS
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![BU of 3hxs by Molmil](/molmil-images/mine/3hxs) | Crystal Structure of Bacteroides fragilis TrxP | Descriptor: | Thioredoxin, ZINC ION | Authors: | Shouldice, S.R. | Deposit date: | 2009-06-22 | Release date: | 2010-01-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.996 Å) | Cite: | In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling Mol.Microbiol., 75, 2010
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3HYP
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![BU of 3hyp by Molmil](/molmil-images/mine/3hyp) | |
1A2M
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![BU of 1a2m by Molmil](/molmil-images/mine/1a2m) | |
1A2L
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![BU of 1a2l by Molmil](/molmil-images/mine/1a2l) | REDUCED DSBA AT 2.7 ANGSTROMS RESOLUTION | Descriptor: | DISULFIDE BOND FORMATION PROTEIN | Authors: | Martin, J.L, Guddat, L.W. | Deposit date: | 1998-01-06 | Release date: | 1998-07-08 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structures of reduced and oxidized DsbA: investigation of domain motion and thiolate stabilization. Structure, 6, 1998
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1A2J
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![BU of 1a2j by Molmil](/molmil-images/mine/1a2j) | OXIDIZED DSBA CRYSTAL FORM II | Descriptor: | DISULFIDE BOND FORMATION PROTEIN | Authors: | Martin, J.L, Guddat, L.W. | Deposit date: | 1998-01-06 | Release date: | 1998-09-16 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of reduced and oxidized DsbA: investigation of domain motion and thiolate stabilization. Structure, 6, 1998
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5VNA
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![BU of 5vna by Molmil](/molmil-images/mine/5vna) | Crystal structure of human YEATS domain | Descriptor: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, SULFATE ION, ... | Authors: | Cho, H.J, Cierpicki, T. | Deposit date: | 2017-04-29 | Release date: | 2018-09-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode. ACS Chem. Biol., 13, 2018
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2RJT
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![BU of 2rjt by Molmil](/molmil-images/mine/2rjt) | |