7ND1

First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain

Summary for 7ND1

• Entry DOI: 10.2210/pdb7nd1/pdb
• Descriptor: E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, ZINC ION, ... (4 entities in total)
• Functional Keywords: polycomb repressive complex 1 (prc1), inhibitor, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 25121.32

Authors

Cierpicki, T.,Lund, G.,Jaremko, L. (deposition date: 2021-01-29, release date: 2021-06-16, Last modification date: 2021-07-07)

• Primary citation: Shukla, S.,Ying, W.,Gray, F.,Yao, Y.,Simes, M.L.,Zhao, Q.,Miao, H.,Cho, H.J.,Gonzalez-Alonso, P.,Winkler, A.,Lund, G.,Purohit, T.,Kim, E.,Zhang, X.,Ray, J.M.,He, S.,Nikolaidis, C.,Ndoj, J.,Wang, J.,Jaremko, L.,Jaremko, M.,Ryan, R.J.H.,Guzman, M.L.,Grembecka, J.,Cierpicki, T.; Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.; Nat.Chem.Biol., 17:784-793, 2021; PubMed: 34155404; DOI: 10.1038/s41589-021-00815-5

Experimental method

SOLUTION NMR