7ND1
First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase RING2 | polymer | 112 | 12767.0 | 1 | UniProt (Q99496) Pfam (PF13923) | Homo sapiens (Human) | Huntingtin-interacting protein 2-interacting protein 3,HIP2-interacting protein 3,Protein DinG,RING finger protein 1B,RING1b,RING finger protein 2,RING finger protein BAP-1,RING-type E3 ubiquitin transferase RING2 |
| 2 | B (H) | Polycomb complex protein BMI-1 | polymer | 101 | 11727.9 | 1 | UniProt (P35226) Pfam (PF13923) | Homo sapiens (Human) | Polycomb group RING finger protein 4,RING finger protein 51 |
| 3 | C, D, F, G (A, H) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | E (A) | 3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid | non-polymer | 364.8 | 1 | Chemie (U9E) |
Sequence modifications
A: 10 - 116 (UniProt: Q99496)
| PDB | External Database | Details |
|---|---|---|
| Gly 8 | - | expression tag |
| Pro 9 | - | expression tag |
| Met 117 | - | expression tag |
| His 118 | - | expression tag |
| Arg 119 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24494.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 626.5 | |
| All* | Total formula weight | 25121.3 |
