7ND1

First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	E3 ubiquitin-protein ligase RING2	polymer	112	12767.0	1	UniProt (Q99496) Pfam (PF13923) In PDB	Homo sapiens (Human)	Huntingtin-interacting protein 2-interacting protein 3,HIP2-interacting protein 3,Protein DinG,RING finger protein 1B,RING1b,RING finger protein 2,RING finger protein BAP-1,RING-type E3 ubiquitin transferase RING2
2	H	Polycomb complex protein BMI-1	polymer	101	11727.9	1	UniProt (P35226) Pfam (PF13923) In PDB	Homo sapiens (Human)	Polycomb group RING finger protein 4,RING finger protein 51
3	A, H	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	A	3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid	non-polymer		364.8	1	Chemie (U9E)

Sequence modifications

A: 10 - 116 (UniProt: Q99496)

PDB	External Database	Details
Gly 8	-	expression tag
Pro 9	-	expression tag
Met 117	-	expression tag
His 118	-	expression tag
Arg 119	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	24494.9
Non-Polymers*	Number of molecules	5
	Total formula weight	626.5
All*	Total formula weight	25121.3

*Water molecules are not included.