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3EBI

Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog

Summary for 3EBI
Entry DOI10.2210/pdb3ebi/pdb
Related3EBG 3EBH
DescriptorM1 family aminopeptidase, ZINC ION, (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, ... (6 entities in total)
Functional Keywordshydrolase, aminopeptidase, metal-binding, metalloprotease, protease, hydrolase inhibitor
Biological sourcePlasmodium falciparum
Cellular locationCytoplasm: O96935
Total number of polymer chains1
Total formula weight104745.19
Authors
McGowan, S.,Porter, C.J.,Buckle, A.M.,Whisstock, J.C. (deposition date: 2008-08-27, release date: 2009-01-27, Last modification date: 2024-02-21)
Primary citationMcGowan, S.,Porter, C.J.,Lowther, J.,Stack, C.M.,Golding, S.J.,Skinner-Adams, T.S.,Trenholme, K.R.,Teuscher, F.,Donnelly, S.M.,Grembecka, J.,Mucha, A.,Kafarski, P.,Degori, R.,Buckle, A.M.,Gardiner, D.L.,Whisstock, J.C.,Dalton, J.P.
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
Proc.Natl.Acad.Sci.USA, 106:2537-2542, 2009
Cited by
PubMed: 19196988
DOI: 10.1073/pnas.0807398106
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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