3EBI
Structure of the M1 Alanylaminopeptidase from malaria complexed with the phosphinate dipeptide analog
Summary for 3EBI
Entry DOI | 10.2210/pdb3ebi/pdb |
Related | 3EBG 3EBH |
Descriptor | M1 family aminopeptidase, ZINC ION, (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, ... (6 entities in total) |
Functional Keywords | hydrolase, aminopeptidase, metal-binding, metalloprotease, protease, hydrolase inhibitor |
Biological source | Plasmodium falciparum |
Cellular location | Cytoplasm: O96935 |
Total number of polymer chains | 1 |
Total formula weight | 104745.19 |
Authors | McGowan, S.,Porter, C.J.,Buckle, A.M.,Whisstock, J.C. (deposition date: 2008-08-27, release date: 2009-01-27, Last modification date: 2024-02-21) |
Primary citation | McGowan, S.,Porter, C.J.,Lowther, J.,Stack, C.M.,Golding, S.J.,Skinner-Adams, T.S.,Trenholme, K.R.,Teuscher, F.,Donnelly, S.M.,Grembecka, J.,Mucha, A.,Kafarski, P.,Degori, R.,Buckle, A.M.,Gardiner, D.L.,Whisstock, J.C.,Dalton, J.P. Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase Proc.Natl.Acad.Sci.USA, 106:2537-2542, 2009 Cited by PubMed: 19196988DOI: 10.1073/pnas.0807398106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report