4R0L

Anti-canine CD28 antibody, 1C6, bound canine CD28

Summary for 4R0L

• Entry DOI: 10.2210/pdb4r0l/pdb
• Related: 4LCI
• Descriptor: Antibody 1C6 Heavy chain, T-cell costimulatory molecule CD28, Antibody 1C6 Light chain, ... (7 entities in total)
• Functional Keywords: immunoglobulin, t-cell activation, cd28, 1c6, immune system
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 6
• Total formula weight: 85643.03

Authors

Gewe, M.M.,Strong, R.K. (deposition date: 2014-07-31, release date: 2015-07-08, Last modification date: 2024-11-06)

Primary citation

Rosinski, S.L.,Storb, R.,Strong, R.K.,Sale, G.E.,Stone, D.M.,Gewe, M.M.,Friend, D.J.,Abrams, V.K.,Randolph-Habecker, J.,Graves, S.S.
Anti-CD28 Antibody-Initiated Cytokine Storm in Canines.
Transplant Direct, 1:-, 2015

PubMed Abstract: CD28 signal blockade following T cell receptor activation is under intense investigation as a tolerance-inducing therapy for transplantation. Our goal is to produce a CD28-specific reagent as a therapy for the prevention of graft rejection and graft-versus-host disease in the canine model of allogeneic hematopoietic cell transplantation (HCT).

PubMed: 25988188
DOI: 10.1097/TXD.0000000000000516

Experimental method

X-RAY DIFFRACTION (3.3 Å)