4R0L

Anti-canine CD28 antibody, 1C6, bound canine CD28

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, H)	Antibody 1C6 Heavy chain	polymer	121	13651.2	2		Mus musculus (mouse)
2	B, C (C, D)	T-cell costimulatory molecule CD28	polymer	129	14854.8	2	UniProt (Q9N0N8)	Canis lupus familiaris (dog)
3	E, F (L, B)	Antibody 1C6 Light chain	polymer	117	12979.7	2		Mus musculus (mouse)
4	G, I (E, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
5	H (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	J, K, L, M, N (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
7	O, P (C, L)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

C, D: 1 - 118 (UniProt: Q9N0N8)

PDB	External Database	Details
Ser 0	-	expression tag
Ser 119	-	expression tag
Ala 120	-	expression tag
Trp 121	-	expression tag
Ser 122	-	expression tag
His 123	-	expression tag
Pro 124	-	expression tag
Gln 125	-	expression tag
Phe 126	-	expression tag
Glu 127	-	expression tag
Lys 128	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	82971.5
Branched	Number of molecules	3
	Total formula weight	1565.5
Non-Polymers*	Number of molecules	5
	Total formula weight	1106.0
All*	Total formula weight	85643.0

*Water molecules are not included.