6WI8

Inhibitor compound-induced confrontational change in Ring1b-Bmi1 domain structure

Summary for 6WI8

Entry DOI	10.2210/pdb6wi8/pdb
Descriptor	E3 ubiquitin-protein ligase RING2,Polycomb complex protein BMI-1 chimera, ZINC ION (3 entities in total)
Functional Keywords	e3 ubiquitin ligase ring1b, bmi1, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	49168.70
Authors	Cho, H.J.,Cierpicki, T. (deposition date: 2020-04-09, release date: 2021-04-14, Last modification date: 2023-10-18)
Primary citation	Shukla, S.,Ying, W.,Gray, F.,Yao, Y.,Simes, M.L.,Zhao, Q.,Miao, H.,Cho, H.J.,Gonzalez-Alonso, P.,Winkler, A.,Lund, G.,Purohit, T.,Kim, E.,Zhang, X.,Ray, J.M.,He, S.,Nikolaidis, C.,Ndoj, J.,Wang, J.,Jaremko, L.,Jaremko, M.,Ryan, R.J.H.,Guzman, M.L.,Grembecka, J.,Cierpicki, T. Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain. Nat.Chem.Biol., 17:784-793, 2021 Cited by PubMed: 34155404 DOI: 10.1038/s41589-021-00815-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.092 Å)

Structure validation