6WI8

Inhibitor compound-induced confrontational change in Ring1b-Bmi1 domain structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	E3 ubiquitin-protein ligase RING2,Polycomb complex protein BMI-1 chimera	polymer	211	24322.7	2	UniProt (X6RFN3) UniProt (P35226) Pfam (PF13923) UniProt (by SIFTS) (Q99496)	Homo sapiens (Human)	Polycomb group RING finger protein 4,RING finger protein 51
2	C, D, E, F, G... (A, B)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
3	K, L (A, B)	water	water		18.0	5	Chemie (HOH)

Sequence modifications

A, B: 10 - 1000 (UniProt: X6RFN3)
A, B: 1001 - 1104 (UniProt: P35226)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48645.4
Non-Polymers*	Number of molecules	8
	Total formula weight	523.3
All*	Total formula weight	49168.7

*Water molecules are not included.