2JYI

Solution structure of MLL CXXC domain

Summary for 2JYI

• Entry DOI: 10.2210/pdb2jyi/pdb
• Related: 2j2s
• Descriptor: Zinc finger protein HRX, ZINC ION (2 entities in total)
• Functional Keywords: protein, cxxc domain, mll, alternative splicing, bromodomain, chromosomal rearrangement, dna-binding, metal-binding, nucleus, phosphoprotein, polymorphism, proto-oncogene, transcription, transcription regulation, ubl conjugation, zinc, zinc-finger
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus. MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• Total number of polymer chains: 1
• Total formula weight: 6664.68

Authors

Cierpicki, T.,Bushweller, J.H. (deposition date: 2007-12-13, release date: 2008-12-09, Last modification date: 2024-05-29)

• Primary citation: Cierpicki, T.,Riesbeck, L.E.,Grembecka, J.,Lukasik, S.M.,Omonkowska, M.,Shultis, D.,Zeleznik-Le, N.J.,Bushweller, J.H.; Structural basis for maintenance of unmethylated CpG elements by the CXXC domain of MLL and its critical contributions to MLL-AF9 immortalization activity; To be Published,

Experimental method

SOLUTION NMR