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5W6M
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BU of 5w6m by Molmil
Crystal structure of the human histidyl-tRNA synthetase mutant D175E
Descriptor: Histidine--tRNA ligase, cytoplasmic
Authors:Blocquel, D, Yang, X.L.
Deposit date:2017-06-16
Release date:2018-06-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.696 Å)
Cite:CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 2019
3D2O
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BU of 3d2o by Molmil
Crystal Structure of Manganese-metallated GTP Cyclohydrolase Type IB
Descriptor: AZIDE ION, CHLORIDE ION, LITHIUM ION, ...
Authors:Swairjo, M.A.
Deposit date:2008-05-08
Release date:2009-05-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB
J.Bacteriol., 191, 2009
2GVK
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BU of 2gvk by Molmil
Crystal structure of a dye-decolorizing peroxidase (DyP) from Bacteroides thetaiotaomicron VPI-5482 at 1.6 A resolution
Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2006-05-02
Release date:2006-05-16
Last modified:2023-01-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.
Proteins, 69, 2007
3WQY
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BU of 3wqy by Molmil
Crystal structure of Archaeoglobus fulgidus alanyl-tRNA synthetase in complex with wild-type tRNA(Ala) having G3.U70
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, Alanine--tRNA ligase, MAGNESIUM ION, ...
Authors:Naganuma, M, Sekine, S, Yokoyama, S.
Deposit date:2014-02-05
Release date:2014-06-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The selective tRNA aminoacylation mechanism based on a single G.U pair
Nature, 510, 2014
3WQZ
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BU of 3wqz by Molmil
Crystal structure of Archaeoglobus fulgidus alanyl-tRNA synthetase in complex with a tRNA(Ala) variant having A3.U70
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, Alanine--tRNA ligase, RNA (75-MER), ...
Authors:Naganuma, M, Sekine, S, Yokoyama, S.
Deposit date:2014-02-05
Release date:2014-06-18
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (3.489 Å)
Cite:The selective tRNA aminoacylation mechanism based on a single G.U pair
Nature, 510, 2014
2HAG
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BU of 2hag by Molmil
Crystal structure of a putative dyp-type peroxidase protein (so_0740) from shewanella oneidensis at 2.75 A resolution
Descriptor: Melanin biosynthesis protein TyrA, putative
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2006-06-12
Release date:2006-08-08
Last modified:2023-01-25
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.
Proteins, 69, 2007
6O76
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BU of 6o76 by Molmil
Human cytosolic Histidyl-tRNA synthetase (HisRS) with WHEP domain
Descriptor: CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic
Authors:Kuhle, B, Yang, X.L.
Deposit date:2019-03-07
Release date:2019-09-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.787 Å)
Cite:CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells.
Proc.Natl.Acad.Sci.USA, 116, 2019
2PMF
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BU of 2pmf by Molmil
The crystal structure of a human glycyl-tRNA synthetase mutant
Descriptor: CHLORIDE ION, GLYCEROL, Glycyl-tRNA synthetase
Authors:Xie, W.
Deposit date:2007-04-21
Release date:2007-05-22
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Long-range structural effects of a Charcot-Marie- Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2PME
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BU of 2pme by Molmil
The Apo crystal Structure of the glycyl-tRNA synthetase
Descriptor: Glycyl-tRNA synthetase
Authors:Xie, W.
Deposit date:2007-04-21
Release date:2007-05-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Long-range structural effects of a Charcot-Marie- Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2G36
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BU of 2g36 by Molmil
Crystal structure of Tryptophanyl-tRNA synthetase (EC 6.1.1.2) (Tryptophan-tRNA ligase)(TrpRS) (tm0492) from THERMOTOGA MARITIMA at 2.50 A resolution
Descriptor: IRON/SULFUR CLUSTER, TRYPTOPHAN, Tryptophanyl-tRNA synthetase
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2006-02-17
Release date:2006-03-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster.
Acta Crystallogr.,Sect.F, 66, 2010
4EQG
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BU of 4eqg by Molmil
Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Ala-AMS
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Histidine triad nucleotide-binding protein 1
Authors:Wang, J, Fang, P, Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
4EQH
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BU of 4eqh by Molmil
Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Trp-AMS
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(L-TRYPTOPHYLAMINO)SULFONYL]ADENOSINE, Histidine triad nucleotide-binding protein 1
Authors:Wang, J, Fang, P, Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.668 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
4DPG
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BU of 4dpg by Molmil
Crystal Structure of Human LysRS: P38/AIMP2 Complex I
Descriptor: ALANINE, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Fang, P, Wang, J, Bennett, S.P, Guo, M.
Deposit date:2012-02-13
Release date:2013-02-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.844 Å)
Cite:Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription.
Mol.Cell, 49, 2013
4EQE
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BU of 4eqe by Molmil
Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Lys-AMS
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Histidine triad nucleotide-binding protein 1
Authors:Wang, J, Fang, P, Guo, M.
Deposit date:2012-04-18
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Side chain independent recognition of aminoacyl adenylates by the hint1 transcription suppressor.
J.Phys.Chem.B, 116, 2012
5THL
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BU of 5thl by Molmil
Crystal structure of the human tyrosyl-tRNA synthetase mutant G41R
Descriptor: Tyrosine--tRNA ligase, cytoplasmic
Authors:Blocquel, D, Sajish, M, Yang, X.L.
Deposit date:2016-09-29
Release date:2017-06-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5THH
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BU of 5thh by Molmil
Crystal structure of a human tyrosyl-tRNA synthetase mutant
Descriptor: TYROSINE, Tyrosine--tRNA ligase, cytoplasmic
Authors:Blocquel, D, Yang, X.L.
Deposit date:2016-09-29
Release date:2017-05-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.959 Å)
Cite:Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
Nucleic Acids Res., 45, 2017
5UJJ
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BU of 5ujj by Molmil
Crystal structure of human H130R tryptophanyl-tRNA synthetase in complex with TrpAMP
Descriptor: MAGNESIUM ION, TRYPTOPHANYL-5'AMP, Tryptophan--tRNA ligase, ...
Authors:Xu, X, Yang, X.-L.
Deposit date:2017-01-18
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function.
RNA Biol, 15, 2018
1KMN
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BU of 1kmn by Molmil
HISTIDYL-TRNA SYNTHETASE COMPLEXED WITH HISTIDINOL AND ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, HISTIDYL-TRNA SYNTHETASE, L-histidinol
Authors:Arnez, J.G, Francklyn, C.S, Moras, D.
Deposit date:1997-05-09
Release date:1997-12-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase.
Proc.Natl.Acad.Sci.USA, 94, 1997
1KMM
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BU of 1kmm by Molmil
HISTIDYL-TRNA SYNTHETASE COMPLEXED WITH HISTIDYL-ADENYLATE
Descriptor: HISTIDYL-ADENOSINE MONOPHOSPHATE, HISTIDYL-TRNA SYNTHETASE
Authors:Arnez, J.G, Francklyn, C.S, Moras, D.
Deposit date:1997-05-09
Release date:1997-12-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase.
Proc.Natl.Acad.Sci.USA, 94, 1997
1HTT
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BU of 1htt by Molmil
HISTIDYL-TRNA SYNTHETASE
Descriptor: ADENOSINE MONOPHOSPHATE, HISTIDINE, HISTIDYL-TRNA SYNTHETASE
Authors:Arnez, J.G, Harris, D.C, Mitschler, A, Rees, B, Francklyn, C.S, Moras, D.
Deposit date:1996-03-09
Release date:1997-01-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of histidyl-tRNA synthetase from Escherichia coli complexed with histidyl-adenylate.
EMBO J., 14, 1995
2ZT5
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BU of 2zt5 by Molmil
Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with ATP)
Descriptor: BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Glycyl-tRNA synthetase
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT7
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BU of 2zt7 by Molmil
Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Glycine and ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GLYCINE, Glycyl-tRNA synthetase
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT6
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BU of 2zt6 by Molmil
Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, Glycyl-tRNA synthetase
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZT8
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BU of 2zt8 by Molmil
Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with Gly-AMP analog
Descriptor: Glycyl-tRNA synthetase, [(2S,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (aminoacetyl)sulfamate
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-09-19
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
2ZXF
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BU of 2zxf by Molmil
Crystal structure of human glycyl-trna synthetase (GLYRS) in complex with AP4A (cocrystallized with AP4A)
Descriptor: BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Glycyl-tRNA synthetase
Authors:Guo, R.T, Yang, X.L, Schimmel, P.
Deposit date:2008-12-23
Release date:2009-08-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Crystal structures and biochemical analyses suggest unique mechanism and role for human GlyRS in Ap4A homeostasis
To be Published
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