5THH

Crystal structure of a human tyrosyl-tRNA synthetase mutant

Summary for 5THH

Entry DOI	10.2210/pdb5thh/pdb
Related	5THL
Descriptor	Tyrosine--tRNA ligase, cytoplasmic, TYROSINE (3 entities in total)
Functional Keywords	tyrosyl-trna synthetase, cmt mutant, ligase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P54577
Total number of polymer chains	1
Total formula weight	38573.66
Authors	Blocquel, D.,Yang, X.L. (deposition date: 2016-09-29, release date: 2017-05-17, Last modification date: 2023-10-04)
Primary citation	Blocquel, D.,Li, S.,Wei, N.,Daub, H.,Sajish, M.,Erfurth, M.L.,Kooi, G.,Zhou, J.,Bai, G.,Schimmel, P.,Jordanova, A.,Yang, X.L. Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy. Nucleic Acids Res., 45:8091-8104, 2017 Cited by PubMed: 28531329 DOI: 10.1093/nar/gkx455 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.959 Å)

Structure validation