5THH

Crystal structure of a human tyrosyl-tRNA synthetase mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004831	molecular_function	tyrosine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006437	biological_process	tyrosyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue TYR A 401

Chain	Residue
A	TYR39
A	GLN182
A	GLN188
A	HOH537
A	HOH571
A	HOH648
A	HOH685
A	GLY41
A	LEU72
A	ALA74
A	HIS77
A	VAL152
A	TYR166
A	GLN170
A	ASP173

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"'HIGH' region","evidences":[{"source":"PubMed","id":"14671330","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"22291016","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25533949","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4Q93","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14671330","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4QBT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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