8DMM
| Structure of the vanadate-trapped MsbA bound to KDL | Descriptor: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]-5-oxidanyl-oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, ADP ORTHOVANADATE, ATP-binding transport protein MsbA | Authors: | Liu, C, Lyu, J, Laganowsky, A.D, Zhao, M. | Deposit date: | 2022-07-08 | Release date: | 2022-12-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural basis for lipid and copper regulation of the ABC transporter MsbA. Nat Commun, 13, 2022
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7KFZ
| Structure of a ternary KRas(G13D)-SOS complex | Descriptor: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Liu, C, Moghadamchargari, Z, Laganowsky, A, Zhao, M. | Deposit date: | 2020-10-15 | Release date: | 2021-03-31 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants. Proc.Natl.Acad.Sci.USA, 118, 2021
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8DZJ
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3HYB
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7E3C
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7E39
| SARS-CoV-2 spike in complex with the Ab4 neutralizing antibody (State 3) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Ab4, Light Chain of Ab4, ... | Authors: | Liu, C. | Deposit date: | 2021-02-08 | Release date: | 2021-09-01 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Three epitope-distinct human antibodies from RenMab mice neutralize SARS-CoV-2 and cooperatively minimize the escape of mutants. Cell Discov, 7, 2021
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7E3B
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4E0N
| SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form II) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), PHOSPHATE ION | Authors: | Zhao, M, Liu, C, Michael, S.R, Eisenberg, D. | Deposit date: | 2012-03-04 | Release date: | 2012-12-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Proc.Natl.Acad.Sci.USA, 109, 2012
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4E0M
| SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form I) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), PHOSPHATE ION | Authors: | Zhao, M, Liu, C, Michael, S.R, Eisenberg, D. | Deposit date: | 2012-03-04 | Release date: | 2013-02-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Out-of-register beta-sheets suggest a pathway
to toxic amyloid aggregates Proc.Natl.Acad.Sci.USA, 109, 2012
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4E0L
| FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffold | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide FYLLYYT(ORN)KN(HAO)SA(ORN) | Authors: | Zhao, M, Liu, C, Michael, S.R, Eisenberg, D. | Deposit date: | 2012-03-04 | Release date: | 2012-12-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Proc.Natl.Acad.Sci.USA, 109, 2012
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4E0K
| Crystal Structure of the amyloid-fibril forming peptide KDWSFY derived from human Beta 2 Microglobulin (58-63) | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Amyloidogenic peptide segment KDWSFY, SODIUM ION | Authors: | Zhao, M, Liu, C, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2012-03-04 | Release date: | 2012-12-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Proc.Natl.Acad.Sci.USA, 109, 2012
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4E0O
| SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form III) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), PHOSPHATE ION | Authors: | Zhao, M, Liu, C, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2012-03-04 | Release date: | 2012-12-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates. Proc.Natl.Acad.Sci.USA, 109, 2012
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8HT7
| The N-terminal region of Cdc6 specifically recognizes human DNA G-quadruplex | Descriptor: | DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3'), GLN-ALA-GLN-ALA-THR-ILE-SER-PHE-PRO-LYS-ARG-LYS-LEU-SER-TRP | Authors: | Liu, C, Zhu, G, Geng, Y, Xu, N. | Deposit date: | 2022-12-20 | Release date: | 2023-12-27 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The N-terminal region of Cdc6 specifically recognizes human DNA G-quadruplex. Int.J.Biol.Macromol., 260, 2024
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2K3K
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2KLQ
| The solution structure of CBD of human MCM6 | Descriptor: | DNA replication licensing factor MCM6 | Authors: | Liu, C. | Deposit date: | 2009-07-08 | Release date: | 2010-03-02 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6 J.Biol.Chem., 285, 2010
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7F2B
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7F2E
| SARS-CoV-2 nucleocapsid protein C-terminal domain (dodecamer) | Descriptor: | Nucleoprotein, PHOSPHATE ION | Authors: | Liu, C, Jiang, H. | Deposit date: | 2021-06-10 | Release date: | 2021-10-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structures of the SARS-CoV-2 nucleocapsid protein C-terminal domain and development of nucleocapsid-targeting nanobodies. Febs J., 289, 2022
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6KZ4
| YebT domain 5-7 | Descriptor: | Intermembrane transport protein YebT | Authors: | Wang, H.W, Liu, C, Zhang, L. | Deposit date: | 2019-09-23 | Release date: | 2020-01-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM Structure of a Bacterial Lipid Transporter YebT. J.Mol.Biol., 432, 2020
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6KZ3
| YebT domain1-4 | Descriptor: | Intermembrane transport protein YebT | Authors: | Wang, H.W, Liu, C, Zhang, L. | Deposit date: | 2019-09-23 | Release date: | 2020-01-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM Structure of a Bacterial Lipid Transporter YebT. J.Mol.Biol., 432, 2020
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6KVG
| The solution structure of human Orc6 | Descriptor: | Origin recognition complex subunit 6 | Authors: | Liu, C, Xu, N, You, Y, Zhu, G. | Deposit date: | 2019-09-04 | Release date: | 2020-09-09 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis of DNA replication origin recognition by human Orc6 protein binding with DNA. Nucleic Acids Res., 48, 2020
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2LP0
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2LOZ
| The novel binding mode of DLC1 and Tensin2 PTB domain | Descriptor: | Rho GTPase-activating protein 7, Tensin-like C1 domain-containing phosphatase | Authors: | Liu, C, Chen, L, Zhu, G. | Deposit date: | 2012-01-29 | Release date: | 2012-06-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode. J.Biol.Chem., 287, 2012
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7V3P
| Cryo-EM structure of the IGF1R/insulin complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | Authors: | Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C. | Deposit date: | 2021-08-11 | Release date: | 2022-08-17 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the IGF1R/insulin complex To Be Published
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8X7M
| CR-bound E46K alpha-synuclein fibrils | Descriptor: | 4-azanyl-3-[(~{E})-[4-[4-[(~{E})-(1-azanyl-4-sulfo-naphthalen-2-yl)diazenyl]phenyl]phenyl]diazenyl]naphthalene-1-sulfonic acid, Alpha-synuclein | Authors: | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | Deposit date: | 2023-11-24 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils. Proc.Natl.Acad.Sci.USA, 121, 2024
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8X7O
| PiB-bound E46K mutanted alpha-synuclein fibrils | Descriptor: | 2-[4-(methylamino)phenyl]-1,3-benzothiazol-6-ol, Alpha-synuclein | Authors: | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | Deposit date: | 2023-11-24 | Release date: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils. Proc.Natl.Acad.Sci.USA, 121, 2024
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