4E0L

FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffold

Summary for 4E0L

• Entry DOI: 10.2210/pdb4e0l/pdb
• Related: 4E0K 4E0M 4E0N 4E0O
• Descriptor: Cyclic pseudo-peptide FYLLYYT(ORN)KN(HAO)SA(ORN), (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
• Functional Keywords: amyloid, out-of-register, fiber-forming, macrocycle, protein fibril
• Total number of polymer chains: 4
• Total formula weight: 7624.57

Authors

Zhao, M.,Liu, C.,Michael, S.R.,Eisenberg, D. (deposition date: 2012-03-04, release date: 2012-12-19, Last modification date: 2023-11-15)

• Primary citation: Liu, C.,Zhao, M.,Jiang, L.,Cheng, P.N.,Park, J.,Sawaya, M.R.,Pensalfini, A.,Gou, D.,Berk, A.J.,Glabe, C.G.,Nowick, J.,Eisenberg, D.; Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates.; Proc.Natl.Acad.Sci.USA, 109:20913-20918, 2012; PubMed: 23213214; DOI: 10.1073/pnas.1218792109

Experimental method

X-RAY DIFFRACTION (1.7 Å)