6GZM
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![BU of 6gzm by Molmil](/molmil-images/mine/6gzm) | Crystal Structure of Human CKIdelta with A86 | Descriptor: | CITRIC ACID, Casein kinase I isoform delta, GLYCEROL, ... | Authors: | Ben-neriah, Y, Venkatachalam, A, Minzel, W, Fink, A, Snir-Alkalay, I, Vacca, J. | Deposit date: | 2018-07-04 | Release date: | 2018-08-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell, 175, 2018
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4NIA
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![BU of 4nia by Molmil](/molmil-images/mine/4nia) | Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints | Descriptor: | Coat protein, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Larson, S.B, Day, J.S, McPherson, A. | Deposit date: | 2013-11-05 | Release date: | 2014-09-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Satellite tobacco mosaic virus refined to 1.4 angstrom resolution. Acta Crystallogr.,Sect.D, 70, 2014
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2WIP
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![BU of 2wip by Molmil](/molmil-images/mine/2wip) | STRUCTURE OF CDK2-CYCLIN A COMPLEXED WITH 8-ANILINO-1-METHYL-4,5-DIHYDRO- 1H-PYRAZOLO[4,3-H] QUINAZOLINE-3-CARBOXYLIC ACID | Descriptor: | 1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid, CELL DIVISION PROTEIN KINASE 2, CYCLIN-A2, ... | Authors: | Brasca, M.G, Amboldi, N, Ballinari, D, Cameron, A.D, Casale, E, Cervi, G, Colombo, M, Colotta, F, Croci, V, Dalessio, R, Fiorentini, F, Isacchi, A, Mercurio, C, Moretti, W, Panzeri, A, Pastori, W, Pevarello, P, Quartieri, F, Roletto, F, Traquandi, G, Vianello, P, Vulpetti, A, Ciomei, M. | Deposit date: | 2009-05-14 | Release date: | 2009-07-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Identification of N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)Phenyl]Amino}-4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline-3-Carboxamide (Pha-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor. J.Med.Chem., 52, 2009
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5YUM
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![BU of 5yum by Molmil](/molmil-images/mine/5yum) | Crystallographic structures of IlvN.Val/Ile complexes:Conformational selectivity for feedback inhibition of AHASs | Descriptor: | Acetolactate synthase isozyme 1 small subunit, COBALT (II) ION, ISOLEUCINE | Authors: | Sarma, S.P, Bansal, A, Schindelin, H, Demeler, B. | Deposit date: | 2017-11-22 | Release date: | 2018-09-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.432 Å) | Cite: | Crystallographic Structures of IlvN·Val/Ile Complexes: Conformational Selectivity for Feedback Inhibition of Aceto Hydroxy Acid Synthases. Biochemistry, 58, 2019
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4A6V
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![BU of 4a6v by Molmil](/molmil-images/mine/4a6v) | X-ray structures of oxazole hydroxamate EcMetAp-Mn complexes | Descriptor: | CARBONATE ION, MANGANESE (II) ION, METHIONINE AMINOPEPTIDASE, ... | Authors: | Huguet, F, Melet, A, AlvesdeSousa, R, Lieutaud, A, Chevalier, J, Deschamps, P, Tomas, A, Leulliot, N, Pages, J.M, Artaud, I. | Deposit date: | 2011-11-09 | Release date: | 2012-06-13 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Hydroxamic Acids as Potent Inhibitors of Fe(II) and Mn(II) E. Coli Methionine Aminopeptidase: Biological Activities and X-Ray Structures of Oxazole Hydroxamate-Ecmetap-Mn Complexes. Chemmedchem, 7, 2012
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3CC6
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![BU of 3cc6 by Molmil](/molmil-images/mine/3cc6) | Crystal structure of kinase domain of protein tyrosine kinase 2 beta (PTK2B) | Descriptor: | GLYCEROL, MAGNESIUM ION, Protein tyrosine kinase 2 beta | Authors: | Busam, R.D, Lehtio, L, Karlberg, T, Arrowsmith, C.H, Bountra, C, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Helleday, T, Herman, M.D, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, Van den Berg, S, Weigelt, J, Welin, M, Berglund, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-02-25 | Release date: | 2008-03-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of Protein Tyrosine Kinase 2 Beta (PTK2B) Kinase domain. To be Published
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3BRM
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![BU of 3brm by Molmil](/molmil-images/mine/3brm) | Crystal structure of the covalent complex between the Bacillus subtilis glutaminase YbgJ and 5-oxo-L-norleucine formed by reaction of the protein with 6-diazo-5-oxo-L-norleucine | Descriptor: | 5-OXO-L-NORLEUCINE, Glutaminase 1 | Authors: | Singer, A.U, Kim, Y, Dementieva, I, Vinokour, E, Joachimiak, A, Savchenko, A, Yakunin, A. | Deposit date: | 2007-12-21 | Release date: | 2008-05-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis. Biochemistry, 47, 2008
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4G32
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![BU of 4g32 by Molmil](/molmil-images/mine/4g32) | Crystal Structure of a Phospholipid-Lipoxygenase Complex from Pseudomonas aeruginosa at 1.75A (P21212) | Descriptor: | (2R)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(tetradec-5-enoyloxy)propyl (11Z)-octadec-11-enoate, 15S-LIPOXYGENASE, FE (II) ION, ... | Authors: | Carpena, X, Garreta, A, Val-Moraes, S.P, Garcia-Fernandez, Q, Fita, I. | Deposit date: | 2012-07-13 | Release date: | 2013-11-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure and interaction with phospholipids of a prokaryotic lipoxygenase from Pseudomonas aeruginosa. Faseb J., 27, 2013
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5DDP
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![BU of 5ddp by Molmil](/molmil-images/mine/5ddp) | L-glutamine riboswitch bound with L-glutamine | Descriptor: | GLUTAMINE, MAGNESIUM ION, RNA (61-MER), ... | Authors: | Ren, A, Patel, D.J. | Deposit date: | 2015-08-25 | Release date: | 2015-12-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch. Cell Rep, 13, 2015
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3C5N
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![BU of 3c5n by Molmil](/molmil-images/mine/3c5n) | Structure of human TULP1 in complex with IP3 | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Tubby-related protein 1 | Authors: | Busam, R.D, Lehtio, L, Arrowsmith, C.H, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Herman, M.D, Johansson, A, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Moche, M, Nilsson, M.E, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Svensson, L, Thorsell, A.G, Tresaugues, L, Van den Berg, S, Weigelt, J, Welin, M, Berglund, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-31 | Release date: | 2008-04-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of human TULP1 in complex with IP3 To be published
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3TEO
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![BU of 3teo by Molmil](/molmil-images/mine/3teo) | APO Form of carbon disulfide hydrolase (selenomethionine form) | Descriptor: | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, CHLORIDE ION, Carbon disulfide hydrolase | Authors: | Smeulders, M.J, Barends, T.R.M.B, Pol, A, Scherer, A, Zandvoort, M.H, Udvarhelyi, A, Khadem, A, Menzel, A, Hermans, J, Shoeman, R.L, Wessels, H.J.C.T, van den Heuvel, L.P, Russ, L, Schlichting, I, Jetten, M.S.M, Op den Camp, H.J.M. | Deposit date: | 2011-08-15 | Release date: | 2011-10-19 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon. Nature, 478, 2011
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4JAI
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![BU of 4jai by Molmil](/molmil-images/mine/4jai) | Crystal Structure of Aurora Kinase A in complex with N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide | Descriptor: | Aurora kinase A, N-{4-[(6-oxo-5,6-dihydrobenzo[c][1,8]naphthyridin-1-yl)amino]phenyl}benzamide | Authors: | Jiang, X, Josephson, K, Huck, B, Goutopoulos, A, Karra, S. | Deposit date: | 2013-02-18 | Release date: | 2013-05-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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4ZX2
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![BU of 4zx2 by Molmil](/molmil-images/mine/4zx2) | Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid | Descriptor: | (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... | Authors: | Chattopadhyay, D, Swingle, M.R, Salter, E.A, Wierzbicki, A, Honkanen, R.E. | Deposit date: | 2015-05-19 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochem. Pharmacol., 109, 2016
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2XL4
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![BU of 2xl4 by Molmil](/molmil-images/mine/2xl4) | LntA, a virulence factor from Listeria monocytogenes | Descriptor: | GLYCEROL, Listeria nuclear targeted protein A | Authors: | Lebreton, A, Job, V, Tham, T.N, Camejo, A, Mattei, P.J, Regnault, B, Cabanes, D, Dessen, A, Cossart, P, Bierne, H. | Deposit date: | 2010-07-19 | Release date: | 2011-02-02 | Last modified: | 2018-10-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response. Science, 331, 2011
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3PPT
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![BU of 3ppt by Molmil](/molmil-images/mine/3ppt) | REP1-NXSQ fatty acid transporter | Descriptor: | PALMITOLEIC ACID, ReP1-NCXSQ | Authors: | Berberian, G, Bollo, M, Howard, E, Cousido-Siah, A, Mitschler, A, Ayoub, D, Sanglier-Cianferani, S, Van Dorsselaer, A, DiPolo, R, Beauge, L, Petrova, T, Schulze-Briese, C, Wang, M, Podjarny, A. | Deposit date: | 2010-11-25 | Release date: | 2011-12-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.28 Å) | Cite: | Structural and functional studies of ReP1-NCXSQ, a protein regulating the squid nerve Na+/Ca2+ exchanger. Acta Crystallogr.,Sect.D, 68, 2012
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3ZDV
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![BU of 3zdv by Molmil](/molmil-images/mine/3zdv) | Crystal structure of the LecB lectin from Pseudomonas aeruginosa in complex with Methyl 6-(2,4,6-trimethylphenylsulfonylamido)-6-deoxy-alpha-D-mannopyranoside | Descriptor: | 1,2-ETHANEDIOL, 2,4,6-trimethylbenzenesulfonamide, CALCIUM ION, ... | Authors: | Hauck, D, Joachim, I, Frommeyer, B, Varrot, A, Philipp, B, MOller, H.M, Imberty, A, Exner, T.E, Titz, A. | Deposit date: | 2012-11-30 | Release date: | 2013-09-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.41 Å) | Cite: | Discovery of Two Classes of Potent Glycomimetic Inhibitors of Pseudomonas Aeruginosa Lecb with Distinct Binding Modes. Acs Chem.Biol., 8, 2013
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3ZEP
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![BU of 3zep by Molmil](/molmil-images/mine/3zep) | Crystal Structure of JAK3 Kinase Domain in Complex with a Pyrrolopyrazine-2-phenyl Ether Inhibitor | Descriptor: | 2-[[(3R)-3-acetamido-2,3-dihydro-1H-inden-5-yl]oxy]-N-[(1S)-1-cyclopropylethyl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, GLYCEROL, TYROSINE-PROTEIN KINASE JAK3 | Authors: | Kuglstatter, A, Jestel, A, Nagel, S, Boettcher, J, Blaesse, M. | Deposit date: | 2012-12-06 | Release date: | 2013-12-11 | Last modified: | 2016-09-14 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Discovery of a Series of Novel 5H-Pyrrolo[2,3-B]Pyrazine-2-Phenyl Ethers, as Potent Jak3 Kinase Inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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3ZGH
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![BU of 3zgh by Molmil](/molmil-images/mine/3zgh) | Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CELL WALL SURFACE ANCHOR FAMILY PROTEIN, ... | Authors: | Schulte, T, Loefling, J, Mikaelsson, C, Kikhney, A, Hentrich, K, Diamante, A, Ebel, C, Normark, S, Svergun, D, Henriques-Normark, B, Achour, A. | Deposit date: | 2012-12-17 | Release date: | 2014-01-08 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Basic Keratin 10-Binding Domain of the Virulence-Associated Pneumococcal Serine-Rich Protein Psrp Adopts a Novel Mscramm Fold. Open Biol., 4, 2014
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5DDO
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![BU of 5ddo by Molmil](/molmil-images/mine/5ddo) | |
3ZGI
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![BU of 3zgi by Molmil](/molmil-images/mine/3zgi) | Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP | Descriptor: | 1,2-ETHANEDIOL, CELL WALL SURFACE ANCHOR FAMILY PROTEIN, SULFATE ION | Authors: | Schulte, T, Loefling, J, Mikaelsson, C, Kikhney, A, Hentrich, K, Diamante, A, Ebel, C, Normark, S, Svergun, D, Henriques-Normark, B, Achour, A. | Deposit date: | 2012-12-17 | Release date: | 2013-12-25 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The Basic Keratin 10-Binding Domain of the Virulence-Associated Pneumococcal Serine-Rich Protein Psrp Adopts a Novel Mscramm Fold. Open Biol., 4, 2014
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4JAJ
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![BU of 4jaj by Molmil](/molmil-images/mine/4jaj) | Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE | Descriptor: | Aurora kinase A, benzo[c][1,8]naphthyridin-6(5H)-one | Authors: | Jiang, X, Josephson, K, Huck, B, Goutopoulos, A, Karra, S. | Deposit date: | 2013-02-18 | Release date: | 2013-05-22 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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4AHQ
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![BU of 4ahq by Molmil](/molmil-images/mine/4ahq) | Crystal Structure of N-acetylneuraminic acid lyase mutant K165C from Staphylococcus aureus | Descriptor: | N-ACETYLNEURAMINATE LYASE | Authors: | Timms, N, Polyakova, A, Windle, C.L, Trinh, C.H, Nelson, A, Trinh, A.R, Berry, A. | Deposit date: | 2012-02-06 | Release date: | 2013-01-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Insights Into the Recovery of Aldolase Activity in N-Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with Gamma-Thialysine by Using a Chemical Mutagenesis Strategy. Chembiochem, 14, 2013
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2KKX
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![BU of 2kkx by Molmil](/molmil-images/mine/2kkx) | Solution Structure of C-terminal domain of reduced NleG2-3 (residues 90-191) from Pathogenic E. coli O157:H7. Northeast Structural Genomics Consortium and Midwest Center for Structural Genomics target ET109A | Descriptor: | Uncharacterized protein ECs2156 | Authors: | Wu, B, Yee, A, Fares, C, Lemak, A, Semest, A, Claude, M, Singer, A, Edwards, A, Savchenko, A, Montelione, G.T, Joachimiak, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Ontario Centre for Structural Proteomics (OCSP), Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-06-29 | Release date: | 2009-08-25 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases. Plos Pathog., 6, 2010
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4ASX
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![BU of 4asx by Molmil](/molmil-images/mine/4asx) | Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dihydro-Bauerine C | Descriptor: | 1,2-ETHANEDIOL, 7,8-bis(chloranyl)-9-methyl-3,4-dihydro-2H-pyrido[3,4-b]indol-1-one, ACTIVIN RECEPTOR TYPE-2A | Authors: | Williams, E, Chaikuad, A, Canning, P, Kochan, G, Mahajan, P, Cooper, C.D.O, Beltrami, A, Krojer, T, Pohl, B, Bracher, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Bullock, A. | Deposit date: | 2012-05-03 | Release date: | 2012-05-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal Structure of Activin Receptor Type-Iia (Acvr2A) Kinase Domain in Complex with a Beta- Carboline Inhibitor To be Published
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1Q8B
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![BU of 1q8b by Molmil](/molmil-images/mine/1q8b) | |