4ZX2

Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid

Summary for 4ZX2

• Entry DOI: 10.2210/pdb4zx2/pdb
• Related: 1S95 4ZVZ
• Descriptor: Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ... (6 entities in total)
• Functional Keywords: protein phosphatase 5, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 38433.43

Authors

Chattopadhyay, D.,Swingle, M.R.,Salter, E.A.,Wierzbicki, A.,Honkanen, R.E. (deposition date: 2015-05-19, release date: 2016-04-27, Last modification date: 2023-09-27)

• Primary citation: Chattopadhyay, D.,Swingle, M.R.,Salter, E.A.,Wood, E.,D'Arcy, B.,Zivanov, C.,Abney, K.,Musiyenko, A.,Rusin, S.F.,Kettenbach, A.,Yet, L.,Schroeder, C.E.,Golden, J.E.,Dunham, W.H.,Gingras, A.C.,Banerjee, S.,Forbes, D.,Wierzbicki, A.,Honkanen, R.E.; Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.; Biochem. Pharmacol., 109:14-26, 2016; PubMed: 27002182; DOI: 10.1016/j.bcp.2016.03.011

Experimental method

X-RAY DIFFRACTION (1.23 Å)