4ZX2
Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MN A 501 |
| Chain | Residue |
| A | ASP271 |
| A | ASN303 |
| A | HIS352 |
| A | HIS427 |
| A | MN502 |
| A | 4TE503 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 502 |
| Chain | Residue |
| A | MN501 |
| A | 4TE503 |
| A | ASP242 |
| A | HIS244 |
| A | ASP271 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue 4TE A 503 |
| Chain | Residue |
| A | ASP242 |
| A | HIS244 |
| A | ASP271 |
| A | ARG275 |
| A | HIS304 |
| A | ARG400 |
| A | HIS427 |
| A | VAL429 |
| A | PHE446 |
| A | TYR451 |
| A | MN501 |
| A | MN502 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MPD A 504 |
| Chain | Residue |
| A | ASN308 |
| A | PRO376 |
| A | ASP377 |
| A | HOH651 |
| A | HOH711 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MRD A 505 |
| Chain | Residue |
| A | LYS192 |
| A | GLU255 |
| A | HOH670 |
Functional Information from PROSITE/UniProt
| site_id | PS00125 |
| Number of Residues | 6 |
| Details | SER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE |
| Chain | Residue | Details |
| A | LEU300-GLU305 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15577939","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19601647","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1S95","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3H64","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15155720","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 10 |
| Details | M-CSA 472 |
| Chain | Residue | Details |
| A | ASP242 | metal ligand |
| A | HIS427 | activator, metal ligand |
| A | HIS244 | metal ligand |
| A | ASP271 | metal ligand |
| A | ASP274 | activator, proton donor |
| A | ARG275 | transition state stabiliser |
| A | ASN303 | metal ligand, transition state stabiliser |
| A | HIS304 | proton acceptor, proton donor, proton relay |
| A | HIS352 | metal ligand |
| A | ARG400 | transition state stabiliser |
