6GZM
Crystal Structure of Human CKIdelta with A86
Summary for 6GZM
Entry DOI | 10.2210/pdb6gzm/pdb |
Descriptor | Casein kinase I isoform delta, CITRIC ACID, GLYCEROL, ... (5 entities in total) |
Functional Keywords | cdk9, kinase inhibitor, a86, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 69872.60 |
Authors | Ben-neriah, Y.,Venkatachalam, A.,Minzel, W.,Fink, A.,Snir-Alkalay, I.,Vacca, J. (deposition date: 2018-07-04, release date: 2018-08-29, Last modification date: 2024-01-17) |
Primary citation | Minzel, W.,Venkatachalam, A.,Fink, A.,Hung, E.,Brachya, G.,Burstain, I.,Shaham, M.,Rivlin, A.,Omer, I.,Zinger, A.,Elias, S.,Winter, E.,Erdman, P.E.,Sullivan, R.W.,Fung, L.,Mercurio, F.,Li, D.,Vacca, J.,Kaushansky, N.,Shlush, L.,Oren, M.,Levine, R.,Pikarsky, E.,Snir-Alkalay, I.,Ben-Neriah, Y. Small Molecules Co-targeting CKI alpha and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell, 175:171-185.e25, 2018 Cited by PubMed: 30146162DOI: 10.1016/j.cell.2018.07.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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