4JAJ

Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE

Summary for 4JAJ

• Entry DOI: 10.2210/pdb4jaj/pdb
• Related: 4JAI
• Descriptor: Aurora kinase A, benzo[c][1,8]naphthyridin-6(5H)-one (3 entities in total)
• Functional Keywords: kinase inhibitor complex, atp-binding, cell cycle, cytoplasm, cytoskeleton, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, protein kinase-like cytoplasm, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, centrosome: O14965
• Total number of polymer chains: 1
• Total formula weight: 33241.10

Authors

Jiang, X.,Josephson, K.,Huck, B.,Goutopoulos, A.,Karra, S. (deposition date: 2013-02-18, release date: 2013-05-22, Last modification date: 2023-09-20)

• Primary citation: Karra, S.,Xiao, Y.,Chen, X.,Liu-Bujalski, L.,Huck, B.,Sutton, A.,Goutopoulos, A.,Askew, B.,Josephson, K.,Jiang, X.,Shutes, A.,Shankar, V.,Noonan, T.,Garcia-Berrios, G.,Dong, R.,Dhanabal, M.,Tian, H.,Wang, Z.,Clark, A.,Goodstal, S.; SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.; Bioorg.Med.Chem.Lett., 23:3081-3087, 2013; PubMed: 23570792; DOI: 10.1016/j.bmcl.2013.03.008

Experimental method

X-RAY DIFFRACTION (2.7 Å)