4JAJ
Crystal Structure of Aurora Kinase A in complex with BENZO[C][1,8]NAPHTHYRIDIN-6(5H)-ONE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aurora kinase A | polymer | 284 | 33044.9 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A |
| 2 | B (A) | benzo[c][1,8]naphthyridin-6(5H)-one | non-polymer | 196.2 | 1 | Chemie (XU1) | |||
| 3 | C (A) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A: 122 - 396 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Met 113 | - | expression tag |
| His 114 | - | expression tag |
| His 115 | - | expression tag |
| His 116 | - | expression tag |
| His 117 | - | expression tag |
| His 118 | - | expression tag |
| His 119 | - | expression tag |
| Gly 120 | - | expression tag |
| Gly 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33044.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 33241.1 |
