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8JT8
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BU of 8jt8 by Molmil
Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ...
Authors:Chen, Z, Fan, L, Wang, S.
Deposit date:2023-06-21
Release date:2024-02-28
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Flexible scaffold-based cheminformatics approach for polypharmacological drug design.
Cell, 187, 2024
8JT6
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BU of 8jt6 by Molmil
5-HT1A-Gi in complex with compound (R)-IHCH-7179
Descriptor: 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Chen, Z, Xu, P, Huang, S, Xu, H.E, Wang, S.
Deposit date:2023-06-21
Release date:2024-02-28
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Flexible scaffold-based cheminformatics approach for polypharmacological drug design.
Cell, 187, 2024
8T5C
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BU of 8t5c by Molmil
Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 8.11G Heavy Chain, 8.11G Light Chain, ...
Authors:Gorman, J, Kwong, P.D.
Deposit date:2023-06-13
Release date:2024-01-03
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability.
Nat Commun, 15, 2024
8TNH
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BU of 8tnh by Molmil
Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site nanobody G36, ...
Authors:Zhou, T, Kwong, P.D, Xu, J.
Deposit date:2023-08-01
Release date:2024-05-08
Last modified:2024-12-18
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1.
Adv Sci, 11, 2024
8TNI
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BU of 8tni by Molmil
Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP gp120, ...
Authors:Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D, Xu, J.
Deposit date:2023-08-01
Release date:2024-05-08
Last modified:2024-12-18
Method:ELECTRON MICROSCOPY (3.61 Å)
Cite:Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1.
Adv Sci, 11, 2024
8JEI
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BU of 8jei by Molmil
Cryo-EM Structure of the compuond 5c-HCAR3-Gi complex
Descriptor: 3-nitro-4-(propylamino)benzoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Fang, Y, Pan, X.
Deposit date:2023-05-15
Release date:2024-11-20
Method:ELECTRON MICROSCOPY (2.73 Å)
Cite:Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3.
Cell Rep, 43, 2024
8JEF
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BU of 8jef by Molmil
Cryo-EM Structure of the 3HO-HCAR3-Gi complex
Descriptor: (3S)-3-hydroxyoctanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Fang, Y, Pan, X.
Deposit date:2023-05-15
Release date:2024-12-18
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3.
Cell Rep, 43, 2024
8TNG
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BU of 8tng by Molmil
Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site targeting nanobody R27, ...
Authors:Zhou, T, Kwong, P.D, Xu, J.
Deposit date:2023-08-01
Release date:2024-05-08
Last modified:2024-12-18
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1.
Adv Sci, 11, 2024
8TE7
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BU of 8te7 by Molmil
Structure of TRNM-f.01
Descriptor: TRNM-f.01 Fab Heavy Chain, TRNM-f.01 Fab Light Chain
Authors:Bender, M.F, Olia, A.S, Kwong, P.D.
Deposit date:2023-07-05
Release date:2024-07-10
Last modified:2025-01-15
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024
8IJA
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BU of 8ija by Molmil
Cryo-EM structure of human HCAR2-Gi complex with niacin
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Pan, X, Fang, Y.
Deposit date:2023-02-26
Release date:2024-01-03
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
8IJD
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BU of 8ijd by Molmil
Cryo-EM structure of human HCAR2-Gi complex with MK-6892
Descriptor: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Pan, X, Fang, Y.
Deposit date:2023-02-27
Release date:2024-01-03
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
8IJ3
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BU of 8ij3 by Molmil
Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state)
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Pan, X, Fang, Y.
Deposit date:2023-02-24
Release date:2024-01-03
Last modified:2025-06-18
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
8IJB
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BU of 8ijb by Molmil
Cryo-EM structure of human HCAR2-Gi complex with acipimox
Descriptor: 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Pan, X, Fang, Y.
Deposit date:2023-02-27
Release date:2024-01-03
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
8TDX
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BU of 8tdx by Molmil
TRNM-b.01 in complex with HIV Env fusion peptide
Descriptor: Env Fusion Peptide, TRNM-b.01 Fab Heavy Chain, TRNM-b.01 Fab Light Chain
Authors:Olia, A.S, Kwong, P.D.
Deposit date:2023-07-05
Release date:2024-07-10
Last modified:2025-01-15
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024
8TJS
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BU of 8tjs by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO GPZ6-a.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody GPZ6-a.01 Heavy Chain, ...
Authors:Morano, N.C, Becker, J.E, Shapiro, L.
Deposit date:2023-07-24
Release date:2024-07-31
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024
8T6V
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BU of 8t6v by Molmil
Cryo-EM structure of human Anion Exchanger 1 bound to 4,4'-Diisothiocyanatostilbene-2,2'-Disulfonic Acid (DIDS)
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, ...
Authors:Capper, M.J, Zilberg, G, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D.
Deposit date:2023-06-18
Release date:2023-09-13
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Substrate binding and inhibition of the anion exchanger 1 transporter.
Nat.Struct.Mol.Biol., 30, 2023
8T6U
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BU of 8t6u by Molmil
Cryo-EM structure of human Anion Exchanger 1 bound to Dipyridamole
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Capper, M.J, Zilberg, G, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D.
Deposit date:2023-06-18
Release date:2023-09-13
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Substrate binding and inhibition of the anion exchanger 1 transporter.
Nat.Struct.Mol.Biol., 30, 2023
8TNU
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BU of 8tnu by Molmil
Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
Authors:Roark, R.S, Morano, N.C, Shapiro, L.S, Kwong, P.D.
Deposit date:2023-08-02
Release date:2024-08-07
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024
8TOP
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BU of 8top by Molmil
Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP glycoprotein gp41, ...
Authors:Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D.
Deposit date:2023-08-03
Release date:2024-08-07
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024
8TO9
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BU of 8to9 by Molmil
Cryo-EM structure of TRNM-f*01 Fab in complex with HIV-1 Env trimer ConC SOSIP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
Authors:Roark, R.S, Morano, N.C, Shapiro, L.S, Kwong, P.D.
Deposit date:2023-08-03
Release date:2024-08-07
Last modified:2025-05-14
Method:ELECTRON MICROSCOPY (4.03 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024
8TOX
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BU of 8tox by Molmil
Cryo-EM structure of BG505 Env mutant A517E in complex with antibody ACS202 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ...
Authors:Wang, S, Kwong, P.D.
Deposit date:2023-08-04
Release date:2024-08-14
Last modified:2025-02-26
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide.
Front Immunol, 15, 2024
8TL2
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BU of 8tl2 by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-c.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
Authors:Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
Deposit date:2023-07-26
Release date:2024-08-28
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024
8TL3
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BU of 8tl3 by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-d.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP glycoprotein gp120, ...
Authors:Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
Deposit date:2023-07-26
Release date:2024-08-28
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024
8TL5
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BU of 8tl5 by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
Authors:Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
Deposit date:2023-07-26
Release date:2024-08-28
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024
8TKC
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BU of 8tkc by Molmil
CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-b.01 FAB
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ...
Authors:Pletnev, S, Hoyt, F, Fischer, E, Kwong, P.
Deposit date:2023-07-25
Release date:2024-08-28
Last modified:2025-01-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques.
Cell, 187, 2024

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