8JT8
 
 | Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | Authors: | Chen, Z, Fan, L, Wang, S. | Deposit date: | 2023-06-21 | Release date: | 2024-02-28 | Last modified: | 2024-11-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187, 2024
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8JT6
 
 | 5-HT1A-Gi in complex with compound (R)-IHCH-7179 | Descriptor: | 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Chen, Z, Xu, P, Huang, S, Xu, H.E, Wang, S. | Deposit date: | 2023-06-21 | Release date: | 2024-02-28 | Last modified: | 2024-11-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187, 2024
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8T5C
 
 | Lassa GPC Trimer in complex with Fab 8.11G and nanobody D5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8.11G Heavy Chain, 8.11G Light Chain, ... | Authors: | Gorman, J, Kwong, P.D. | Deposit date: | 2023-06-13 | Release date: | 2024-01-03 | Last modified: | 2024-11-20 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability. Nat Commun, 15, 2024
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8TNH
 
 | Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site nanobody G36, ... | Authors: | Zhou, T, Kwong, P.D, Xu, J. | Deposit date: | 2023-08-01 | Release date: | 2024-05-08 | Last modified: | 2024-12-18 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1. Adv Sci, 11, 2024
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8TNI
 
 | Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP gp120, ... | Authors: | Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D, Xu, J. | Deposit date: | 2023-08-01 | Release date: | 2024-05-08 | Last modified: | 2024-12-18 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1. Adv Sci, 11, 2024
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8JEI
 
 | Cryo-EM Structure of the compuond 5c-HCAR3-Gi complex | Descriptor: | 3-nitro-4-(propylamino)benzoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Fang, Y, Pan, X. | Deposit date: | 2023-05-15 | Release date: | 2024-11-20 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3. Cell Rep, 43, 2024
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8JEF
 
 | Cryo-EM Structure of the 3HO-HCAR3-Gi complex | Descriptor: | (3S)-3-hydroxyoctanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Fang, Y, Pan, X. | Deposit date: | 2023-05-15 | Release date: | 2024-12-18 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3. Cell Rep, 43, 2024
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8TNG
 
 | Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site targeting nanobody R27, ... | Authors: | Zhou, T, Kwong, P.D, Xu, J. | Deposit date: | 2023-08-01 | Release date: | 2024-05-08 | Last modified: | 2024-12-18 | Method: | ELECTRON MICROSCOPY (3.58 Å) | Cite: | Ultrapotent Broadly Neutralizing Human-llama Bispecific Antibodies against HIV-1. Adv Sci, 11, 2024
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8TE7
 
 | Structure of TRNM-f.01 | Descriptor: | TRNM-f.01 Fab Heavy Chain, TRNM-f.01 Fab Light Chain | Authors: | Bender, M.F, Olia, A.S, Kwong, P.D. | Deposit date: | 2023-07-05 | Release date: | 2024-07-10 | Last modified: | 2025-01-15 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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8IJA
 
 | Cryo-EM structure of human HCAR2-Gi complex with niacin | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Pan, X, Fang, Y. | Deposit date: | 2023-02-26 | Release date: | 2024-01-03 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
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8IJD
 
 | Cryo-EM structure of human HCAR2-Gi complex with MK-6892 | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Pan, X, Fang, Y. | Deposit date: | 2023-02-27 | Release date: | 2024-01-03 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
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8IJ3
 
 | Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state) | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Pan, X, Fang, Y. | Deposit date: | 2023-02-24 | Release date: | 2024-01-03 | Last modified: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
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8IJB
 
 | Cryo-EM structure of human HCAR2-Gi complex with acipimox | Descriptor: | 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Pan, X, Fang, Y. | Deposit date: | 2023-02-27 | Release date: | 2024-01-03 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Discov, 9, 2023
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8TDX
 
 | TRNM-b.01 in complex with HIV Env fusion peptide | Descriptor: | Env Fusion Peptide, TRNM-b.01 Fab Heavy Chain, TRNM-b.01 Fab Light Chain | Authors: | Olia, A.S, Kwong, P.D. | Deposit date: | 2023-07-05 | Release date: | 2024-07-10 | Last modified: | 2025-01-15 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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8TJS
 
 | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO GPZ6-a.01 FAB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody GPZ6-a.01 Heavy Chain, ... | Authors: | Morano, N.C, Becker, J.E, Shapiro, L. | Deposit date: | 2023-07-24 | Release date: | 2024-07-31 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.31 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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8T6V
 
 | Cryo-EM structure of human Anion Exchanger 1 bound to 4,4'-Diisothiocyanatostilbene-2,2'-Disulfonic Acid (DIDS) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid, ... | Authors: | Capper, M.J, Zilberg, G, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D. | Deposit date: | 2023-06-18 | Release date: | 2023-09-13 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Substrate binding and inhibition of the anion exchanger 1 transporter. Nat.Struct.Mol.Biol., 30, 2023
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8T6U
 
 | Cryo-EM structure of human Anion Exchanger 1 bound to Dipyridamole | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Capper, M.J, Zilberg, G, Mathiharan, Y.K, Yang, S, Stone, A.C, Wacker, D. | Deposit date: | 2023-06-18 | Release date: | 2023-09-13 | Last modified: | 2024-11-06 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Substrate binding and inhibition of the anion exchanger 1 transporter. Nat.Struct.Mol.Biol., 30, 2023
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8TNU
 
 | Cryo-EM structure of TRNM-b*01 Fab in complex with HIV-1 Env trimer BG505.DS SOSIP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ... | Authors: | Roark, R.S, Morano, N.C, Shapiro, L.S, Kwong, P.D. | Deposit date: | 2023-08-02 | Release date: | 2024-08-07 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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8TOP
 
 | Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with antibody GPZ6-b.01 targeting the fusion peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP glycoprotein gp41, ... | Authors: | Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D. | Deposit date: | 2023-08-03 | Release date: | 2024-08-07 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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8TO9
 
 | Cryo-EM structure of TRNM-f*01 Fab in complex with HIV-1 Env trimer ConC SOSIP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Roark, R.S, Morano, N.C, Shapiro, L.S, Kwong, P.D. | Deposit date: | 2023-08-03 | Release date: | 2024-08-07 | Last modified: | 2025-05-14 | Method: | ELECTRON MICROSCOPY (4.03 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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8TOX
 
 | Cryo-EM structure of BG505 Env mutant A517E in complex with antibody ACS202 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | Authors: | Wang, S, Kwong, P.D. | Deposit date: | 2023-08-04 | Release date: | 2024-08-14 | Last modified: | 2025-02-26 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide. Front Immunol, 15, 2024
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8TL2
 
 | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-c.01 FAB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ... | Authors: | Pletnev, S, Hoyt, F, Fischer, E, Kwong, P. | Deposit date: | 2023-07-26 | Release date: | 2024-08-28 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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8TL3
 
 | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-d.01 FAB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP glycoprotein gp120, ... | Authors: | Pletnev, S, Hoyt, F, Fischer, E, Kwong, P. | Deposit date: | 2023-07-26 | Release date: | 2024-08-28 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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8TL5
 
 | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO HERH-c.01 FAB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ... | Authors: | Pletnev, S, Hoyt, F, Fischer, E, Kwong, P. | Deposit date: | 2023-07-26 | Release date: | 2024-08-28 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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8TKC
 
 | CRYO-EM STRUCTURE OF HIV-1 BG505DS-SOSIP.664 ENV TRIMER BOUND TO DJ85-b.01 FAB | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 DS-SOSIP Surface protein gp120, ... | Authors: | Pletnev, S, Hoyt, F, Fischer, E, Kwong, P. | Deposit date: | 2023-07-25 | Release date: | 2024-08-28 | Last modified: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Potent and broad HIV-1 neutralization in fusion peptide-primed SHIV-infected macaques. Cell, 187, 2024
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