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5TD2
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BU of 5td2 by Molmil
Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
Descriptor: N-[2-{4-[(2S)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1H-imidazole-2-carboxamide, Tyrosine-protein kinase Mer
Authors:Hoffman, I.D, Lawson, J.D.
Deposit date:2016-09-16
Release date:2017-01-25
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate.
Bioorg. Med. Chem. Lett., 27, 2017
5UEL
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BU of 5uel by Molmil
Crystal structure of 354NC102 Fab
Descriptor: 354NC102 Fab Heavy Chain, 354NC102 Fab Light Chain, SULFATE ION
Authors:Sievers, S.A, Gristick, H.B, Bjorkman, P.J.
Deposit date:2017-01-02
Release date:2017-02-01
Last modified:2022-04-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Sci Transl Med, 9, 2017
5UD9
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BU of 5ud9 by Molmil
Crystal structure of 354BG18 Fab
Descriptor: Fab heavy chain, Light chain
Authors:Scharf, L, Bjorkman, P.J.
Deposit date:2016-12-23
Release date:2017-02-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Sci Transl Med, 9, 2017
5UEM
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BU of 5uem by Molmil
Crystal structure of 354NC37 Fab in complex with HIV-1 clade AE strain 93TH057 gp120
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 354NC37 Fab Heavy Chain, ...
Authors:Sievers, S.A, Gristick, H.B, Bjorkman, P.J.
Deposit date:2017-01-02
Release date:2018-01-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller.
Sci Transl Med, 9, 2017
4H35
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BU of 4h35 by Molmil
Feruloyl Esterase Domain of XYNY from Clostridium thermocellum before exposure to 266nm UV laser
Descriptor: CADMIUM ION, Endo-1,4-beta-xylanase Y
Authors:Pereira, P.J.B, de Sanctis, D.
Deposit date:2012-09-13
Release date:2012-12-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:In-house UV radiation-damage-induced phasing of selenomethionine-labeled protein structures.
J.Struct.Biol., 181, 2013
8HTX
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BU of 8htx by Molmil
Crystal structure of BANP in complex with methylated DNA
Descriptor: DNA (5'-D(*CP*TP*CP*TP*(5CM)P*GP*CP*GP*AP*GP*AP*G)-3'), Protein BANP
Authors:Zhang, J, Min, J, Liu, K.
Deposit date:2022-12-21
Release date:2023-05-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.
J.Biol.Chem., 299, 2023
7YUN
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BU of 7yun by Molmil
Crystal structure of human BEND6 BEN domain in complex with methylated DNA
Descriptor: BEN domain-containing protein 6, DNA (5'-D(*CP*TP*CP*TP*CP*GP*(5CM)P*GP*AP*GP*AP*G)-3')
Authors:Liu, K, Xiao, Y.Q, Zhang, J, Min, J.R.
Deposit date:2022-08-17
Release date:2023-05-03
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.
J.Biol.Chem., 299, 2023
5HEV
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BU of 5hev by Molmil
Crystal Structure of the beryllofluoride-activated LiaR from Enterococcus faecium
Descriptor: BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Response regulator protein VraR
Authors:Davlieva, M, Shamoo, Y.
Deposit date:2016-01-06
Release date:2016-11-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.192 Å)
Cite:An Adaptive Mutation in Enterococcus faecium LiaR Associated with Antimicrobial Peptide Resistance Mimics Phosphorylation and Stabilizes LiaR in an Activated State.
J.Mol.Biol., 428, 2016
7LSE
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BU of 7lse by Molmil
Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Far Eastern Subtype)
Descriptor: Envelope protein E, GLYCEROL, T025 Fab Heavy Chain, ...
Authors:Keeffe, J.R, Bjorkman, P.J.
Deposit date:2021-02-18
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease.
J.Exp.Med., 218, 2021
7LSF
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BU of 7lsf by Molmil
Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Western Subtype)
Descriptor: Envelope protein E, GLYCEROL, SODIUM ION, ...
Authors:Keeffe, J.R, Bjorkman, P.J.
Deposit date:2021-02-18
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease.
J.Exp.Med., 218, 2021
7YUK
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BU of 7yuk by Molmil
Complex structure of BANP BEN domain bound to DNA
Descriptor: DNA (5'-D(*CP*TP*CP*TP*CP*GP*CP*GP*AP*GP*AP*G)-3'), GLYCEROL, Protein BANP
Authors:Zhang, J, Xiao, Y.Q, Chen, Y.X, Liu, K, Min, J.R.
Deposit date:2022-08-17
Release date:2023-04-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.
J.Biol.Chem., 299, 2023
7YUG
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BU of 7yug by Molmil
Structure of human BANP BEN domain
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, BROMIDE ION, CHLORIDE ION, ...
Authors:Zhang, J, Xiao, Y.Q, Chen, Y.X, Liu, K, Min, J.R.
Deposit date:2022-08-17
Release date:2023-04-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.
J.Biol.Chem., 299, 2023
7YUL
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BU of 7yul by Molmil
Crystal structure of human BEND6 BEN domain in complex with DNA
Descriptor: BEN domain-containing protein 6, DNA (5'-D(*CP*TP*CP*TP*CP*GP*CP*GP*AP*GP*AP*G)-3'), GLYCOLIC ACID
Authors:Liu, K, Xiao, Y.Q, Zhang, J, Min, J.R.
Deposit date:2022-08-17
Release date:2023-04-26
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.
J.Biol.Chem., 299, 2023
7LSG
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BU of 7lsg by Molmil
Crystal structure of the human neutralizing antibody Fab fragment T025 bound to TBEV EDIII (Siberian Subtype)
Descriptor: Core protein, T025 Fab Heavy Chain, T025 Fab Light Chain
Authors:Keeffe, J.R, Bjorkman, P.J.
Deposit date:2021-02-18
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease.
J.Exp.Med., 218, 2021
4NW3
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BU of 4nw3 by Molmil
Crystal structure of MLL CXXC domain in complex with a CpG DNA
Descriptor: 5'-D(*GP*CP*CP*AP*TP*CP*GP*AP*TP*GP*GP*C)-3', Histone-lysine N-methyltransferase 2A, ZINC ION
Authors:Bian, C, Tempel, W, Chao, X, Walker, J.R, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-12-05
Release date:2014-04-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
4O64
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BU of 4o64 by Molmil
Zinc fingers of KDM2B
Descriptor: Lysine-specific demethylase 2B, UNKNOWN ATOM OR ION, ZINC ION
Authors:Liu, K, Xu, C, Tempel, W, Walker, J.R, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2013-12-20
Release date:2014-04-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.
Structure, 26, 2018
1TVT
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BU of 1tvt by Molmil
STRUCTURE OF THE EQUINE INFECTIOUS ANEMIA VIRUS TAT PROTEIN
Descriptor: TRANSACTIVATOR PROTEIN
Authors:Roesch, P, Willbold, D.
Deposit date:1994-07-07
Release date:1995-07-10
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure of the equine infectious anemia virus Tat protein.
Science, 264, 1994
2KBY
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BU of 2kby by Molmil
The Tetramerization Domain of Human p73
Descriptor: Tumor protein p73
Authors:Coutandin, D, Ikeya, T, Loehr, F, Guntert, P, Ou, H.D, Doetsch, V.
Deposit date:2008-12-12
Release date:2009-09-29
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Conformational stability and activity of p73 require a second helix in the tetramerization domain.
Cell Death Differ., 16, 2009
2LI3
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BU of 2li3 by Molmil
Structural and functional analysis of a novel potassium toxin argentinean scorpion Tityus trivittatus reveals a new kappa sub-family
Descriptor: Potassium channel toxin kappa-KTX3.1
Authors:Saucedo-Yanez, A, Del Rio-Portilla, F, Hernandez-Lopez, R.
Deposit date:2011-08-19
Release date:2012-01-11
Last modified:2012-04-25
Method:SOLUTION NMR
Cite:New Tricks of an Old Pattern: STRUCTURAL VERSATILITY OF SCORPION TOXINS WITH COMMON CYSTEINE SPACING.
J.Biol.Chem., 287, 2012
3EQL
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BU of 3eql by Molmil
Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I.
Deposit date:2008-09-30
Release date:2008-10-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Transcription inactivation through local refolding of the RNA polymerase structure.
Nature, 457, 2009
5VIC
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BU of 5vic by Molmil
Crystal structure of anti-Zika antibody Z004 bound to DENV-1 Envelope protein DIII
Descriptor: Dengue 1 Envelope DIII domain, Fab heavy chain, Fab light chain
Authors:Keeffe, J.R, West Jr, A.P, Gristick, H.B, Bjorkman, P.J.
Deposit date:2017-04-14
Release date:2017-05-03
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.
Cell, 169, 2017
7KDE
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BU of 7kde by Molmil
BG505 SOSIP.664 in complex with the V3-targeting rhesus macaque antibody 1485 and human gp120-gp41 interface antibody 8ANC195
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Barnes, C.O, Bjorkman, P.J.
Deposit date:2020-10-08
Release date:2020-10-28
Last modified:2020-11-04
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch.
Elife, 9, 2020
5VIG
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BU of 5vig by Molmil
Crystal structure of anti-Zika antibody Z006 bound to Zika virus envelope protein DIII
Descriptor: CITRATE ANION, Fab heavy chain, Fab light chain, ...
Authors:Keeffe, J.R, West Jr, A.P, Gristick, H.B, Bjorkman, P.J.
Deposit date:2017-04-16
Release date:2017-05-03
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.
Cell, 169, 2017
4BAG
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BU of 4bag by Molmil
Feruloyl Esterase Domain of XYNY from Clostridium thermocellum after exposure to 266nm UV laser
Descriptor: CADMIUM ION, ENDO-1,4-BETA-XYLANASE Y, GLYCEROL
Authors:Pereira, P.J.B, de Sanctis, D.
Deposit date:2012-09-14
Release date:2013-04-17
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:In-House Uv Radiation-Damage-Induced Phasing of Selenomethionine-Labeled Protein Structures.
J.Struct.Biol., 181, 2013
4ALT
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BU of 4alt by Molmil
X-Ray photoreduction of Polysaccharide monooxygenase CBM33
Descriptor: CHITIN BINDING PROTEIN, COPPER (II) ION, DI(HYDROXYETHYL)ETHER
Authors:Gudmundsson, M, Wu, M, Ishida, T, Momeni, M.H, Vaaje-Kolstad, G, Eijsink, V, Sandgren, M.
Deposit date:2012-03-05
Release date:2013-02-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural and Electronic Snapshots During the Transition from a Cu(II) to Cu(I) Metal Center of a Lytic Polysaccharide Monooxygenase by X-Ray Photo-Reduction.
J.Biol.Chem., 289, 2014

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