3HXT
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![BU of 3hxt by Molmil](/molmil-images/mine/3hxt) | Structure of human MTHFS | Descriptor: | 5-formyltetrahydrofolate cyclo-ligase, MAGNESIUM ION, NICKEL (II) ION | Authors: | Wu, D, Li, Y, Song, G, Cheng, C, Zhang, R, Joachimiak, A, Shaw, N, Liu, Z.-J. | Deposit date: | 2009-06-22 | Release date: | 2009-07-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for the inhibition of human 5,10-methenyltetrahydrofolate synthetase by N10-substituted folate analogues Cancer Res., 69, 2009
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3I2V
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![BU of 3i2v by Molmil](/molmil-images/mine/3i2v) | Crystal structure of human MOCS3 rhodanese-like domain | Descriptor: | Adenylyltransferase and sulfurtransferase MOCS3 | Authors: | Bacik, J.P, Walker, J.R, Lopez, L, Li, Y, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-29 | Release date: | 2009-07-21 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Crystal structure of the human MOCS3 rhodanese-like domain To be Published
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7MWL
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![BU of 7mwl by Molmil](/molmil-images/mine/7mwl) | The TAM domain of BAZ2A in complex with a 12mer mCG DNA | Descriptor: | Bromodomain adjacent to zinc finger domain protein 2A, DNA (5'-D(*GP*CP*CP*AP*AP*(5CM)P*GP*TP*TP*GP*GP*C)-3'), GLYCEROL | Authors: | Liu, K, Dong, A, Li, Y, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2021-05-17 | Release date: | 2021-07-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | The TAM domain of BAZ2A in complex with a 12mer mCG DNA To Be Published
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7MIS
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![BU of 7mis by Molmil](/molmil-images/mine/7mis) | Cryo-EM structure of SidJ-SdeC-CaM reaction intermediate complex | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | Authors: | Osinski, A, Black, M.H, Pawlowski, K, Chen, Z, Li, Y, Tagliabracci, V.S. | Deposit date: | 2021-04-17 | Release date: | 2021-08-18 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural and mechanistic basis for protein glutamylation by the kinase fold. Mol.Cell, 81, 2021
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7MIR
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![BU of 7mir by Molmil](/molmil-images/mine/7mir) | Cryo-EM structure of SidJ-SdeA-CaM reaction intermediate complex | Descriptor: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | Authors: | Osinski, A, Black, M.H, Pawlowski, K, Chen, Z, Li, Y, Tagliabracci, V.S. | Deposit date: | 2021-04-17 | Release date: | 2021-08-18 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structural and mechanistic basis for protein glutamylation by the kinase fold. Mol.Cell, 81, 2021
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3GV4
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![BU of 3gv4 by Molmil](/molmil-images/mine/3gv4) | Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG | Descriptor: | CALCIUM ION, Histone deacetylase 6, ZINC ION, ... | Authors: | Dong, A, Ravichandran, M, Loppnau, P, Li, Y, MacKenzie, F, Kozieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Bountra, C, Bochkarev, A, Dhe-Paganon, S, Min, J, Ouyang, H, Structural Genomics Consortium (SGC) | Deposit date: | 2009-03-30 | Release date: | 2009-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG To be Published
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3GUC
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![BU of 3guc by Molmil](/molmil-images/mine/3guc) | Human Ubiquitin-activating Enzyme 5 in Complex with AMPPNP | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ubiquitin-like modifier-activating enzyme 5, ZINC ION | Authors: | Walker, J.R, Bacik, J.P, Li, Y, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-03-29 | Release date: | 2009-05-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Human Ubiquitin-activating Enzyme 5 in Complex with AMPPNP To be Published
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3HCX
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![BU of 3hcx by Molmil](/molmil-images/mine/3hcx) | Crystal structure of E. coli HPPK(N10A) | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CHLORIDE ION | Authors: | Blaszczyk, J, Li, Y, Yan, H, Ji, X. | Deposit date: | 2009-05-06 | Release date: | 2010-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Role of loop coupling in enzymatic catalysis and conformational dynamics To be Published
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3HD2
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![BU of 3hd2 by Molmil](/molmil-images/mine/3hd2) | Crystal structure of E. coli HPPK(Q50A) in complex with MgAMPCPP and pterin | Descriptor: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, CHLORIDE ION, ... | Authors: | Blaszczyk, J, Li, Y, Yan, H, Ji, X. | Deposit date: | 2009-05-06 | Release date: | 2010-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Role of loop coupling in enzymatic catalysis and conformational dynamics To be Published
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3HD1
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![BU of 3hd1 by Molmil](/molmil-images/mine/3hd1) | Crystal structure of E. coli HPPK(N10A) in complex with MgAMPCPP | Descriptor: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ACETATE ION, CHLORIDE ION, ... | Authors: | Blaszczyk, J, Li, Y, Yan, H, Ji, X. | Deposit date: | 2009-05-06 | Release date: | 2010-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Role of loop coupling in enzymatic catalysis and conformational dynamics To be Published
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3FCX
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![BU of 3fcx by Molmil](/molmil-images/mine/3fcx) | Crystal structure of human esterase D | Descriptor: | CALCIUM ION, MAGNESIUM ION, S-formylglutathione hydrolase | Authors: | Wu, D, Li, Y, Song, G, Zhang, D, Shaw, N, Liu, Z.J. | Deposit date: | 2008-11-24 | Release date: | 2008-12-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of human esterase D: a potential genetic marker of retinoblastoma Faseb J., 23, 2009
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3FL2
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![BU of 3fl2 by Molmil](/molmil-images/mine/3fl2) | Crystal structure of the ring domain of the E3 ubiquitin-protein ligase UHRF1 | Descriptor: | E3 ubiquitin-protein ligase UHRF1, ZINC ION | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2008-12-18 | Release date: | 2009-01-20 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of the Ring Domain of the E3 Ubiquitin-Protein Ligase Uhrf1 To be Published
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3IV1
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![BU of 3iv1 by Molmil](/molmil-images/mine/3iv1) | Coiled-coil domain of tumor susceptibility gene 101 | Descriptor: | CHLORIDE ION, SULFATE ION, Tumor susceptibility gene 101 protein | Authors: | Neculai, D, Avvakumov, G.V, Wernimont, A.K, Xue, S, Walker, J.R, Li, Y, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | Deposit date: | 2009-08-31 | Release date: | 2009-11-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Coiled-Coil Domain of Human Tsg101 To be Published
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3S44
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![BU of 3s44 by Molmil](/molmil-images/mine/3s44) | Crystal Structure of Pasteurella multocida sialyltransferase M144D mutant with CMP bound | Descriptor: | Alpha-2,3/2,6-sialyltransferase/sialidase, CMP-3F(a)-Neu5Ac | Authors: | Sugiarto, G, Lau, K, Li, Y, Lim, S, Ames, J.B, Le, D.-T, Fisher, A.J, Chen, X. | Deposit date: | 2011-05-18 | Release date: | 2012-08-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | A Sialyltransferase Mutant with Decreased Donor Hydrolysis and Reduced Sialidase Activities for Directly Sialylating Lewis(x). Acs Chem.Biol., 7, 2012
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3S6K
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![BU of 3s6k by Molmil](/molmil-images/mine/3s6k) | Crystal structure of xcNAGS | Descriptor: | Acetylglutamate kinase | Authors: | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | Deposit date: | 2011-05-25 | Release date: | 2012-04-18 | Method: | X-RAY DIFFRACTION (2.8018 Å) | Cite: | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris. Plos One, 6, 2011
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3S6G
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![BU of 3s6g by Molmil](/molmil-images/mine/3s6g) | Crystal structures of Seleno-substituted mutant mmNAGS in space group P212121 | Descriptor: | 1,2-ETHANEDIOL, COENZYME A, MALONATE ION, ... | Authors: | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | Deposit date: | 2011-05-25 | Release date: | 2012-04-18 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.6681 Å) | Cite: | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris. Plos One, 6, 2011
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3S6H
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![BU of 3s6h by Molmil](/molmil-images/mine/3s6h) | Crystal structure of native mmNAGS/k | Descriptor: | COENZYME A, GLUTAMIC ACID, N-acetylglutamate kinase / N-acetylglutamate synthase | Authors: | Shi, D, Li, Y, Cabrera-Luque, J, Jin, Z, Yu, X, Allewell, N.M, Tuchman, M. | Deposit date: | 2011-05-25 | Release date: | 2012-04-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.102 Å) | Cite: | A Novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris. Plos One, 6, 2011
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2AHV
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![BU of 2ahv by Molmil](/molmil-images/mine/2ahv) | Crystal Structure of Acyl-CoA transferase from E. coli O157:H7 (YdiF)-thioester complex with CoA- 1 | Descriptor: | COENZYME A, putative enzyme YdiF | Authors: | Rangarajan, E.S, Li, Y, Ajamian, E, Iannuzzi, P, Kernaghan, S.D, Fraser, M.E, Cygler, M, Matte, A, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | Deposit date: | 2005-07-28 | Release date: | 2005-11-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystallographic trapping of the glutamyl-CoA thioester intermediate of family I CoA transferases. J.Biol.Chem., 280, 2005
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2FD6
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![BU of 2fd6 by Molmil](/molmil-images/mine/2fd6) | Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A | Descriptor: | 1,2-ETHANEDIOL, 2-ETHOXYETHANOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose, ... | Authors: | Huang, M, Huai, Q, Li, Y. | Deposit date: | 2005-12-13 | Release date: | 2006-02-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of human urokinase plasminogen activator in complex with its receptor Science, 311, 2006
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2AX0
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![BU of 2ax0 by Molmil](/molmil-images/mine/2ax0) | Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x) | Descriptor: | 5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | Authors: | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | Deposit date: | 2005-09-02 | Release date: | 2006-01-24 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49, 2006
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2AWZ
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![BU of 2awz by Molmil](/molmil-images/mine/2awz) | Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h) | Descriptor: | 5R-(4-BROMOPHENYLMETHYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | Authors: | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | Deposit date: | 2005-09-02 | Release date: | 2006-01-24 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49, 2006
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5YOV
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![BU of 5yov by Molmil](/molmil-images/mine/5yov) | Crystal structure of BRD4-BD1 bound with hjp126 | Descriptor: | (3~{R})-4-cyclopentyl-~{N}-(2,4-dimethylphenyl)-1,3-dimethyl-2-oxidanylidene-3~{H}-quinoxaline-6-carboxamide, Bromodomain-containing protein 4 | Authors: | Xiong, B, Hu, J, Li, Y, Cao, D. | Deposit date: | 2017-10-31 | Release date: | 2018-11-07 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.451 Å) | Cite: | Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups. Eur.J.Med.Chem., 150, 2018
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3S4Y
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![BU of 3s4y by Molmil](/molmil-images/mine/3s4y) | Crystal structure of human thiamin pyrophosphokinase 1 | Descriptor: | CALCIUM ION, SULFATE ION, THIAMINE DIPHOSPHATE, ... | Authors: | Shen, L, Tempel, W, Tong, Y, Li, Y, Walker, J.R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2011-05-20 | Release date: | 2011-06-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of human thiamin pyrophosphokinase 1 to be published
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7FI9
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![BU of 7fi9 by Molmil](/molmil-images/mine/7fi9) | Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D | Descriptor: | GLYCEROL, MHC class I polypeptide-related sequence A, NKG2-D type II integral membrane protein | Authors: | Cai, W, Peng, S, Xu, T, Tian, Y, Li, Y, Liu, J. | Deposit date: | 2021-07-30 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D to be published
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7FI7
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![BU of 7fi7 by Molmil](/molmil-images/mine/7fi7) | Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D | Descriptor: | MHC class I polypeptide-related sequence A, NKG2-D type II integral membrane protein | Authors: | Cai, W, Peng, S, Xu, T, Tian, Y, Li, Y, Liu, J. | Deposit date: | 2021-07-30 | Release date: | 2022-08-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D to be published
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