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Crystal Structure of the Bacteriophage T4 recombination mediator protein UvsY, Lattice Type III
Descriptor:	Recombination protein uvsY
Authors:	Gajewski, S, White, S.W.
Deposit date:	2015-05-19
Release date:	2016-03-02
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structure and mechanism of the phage T4 recombination mediator protein UvsY. Proc.Natl.Acad.Sci.USA, 113, 2016

4ZWT

Crystal Structure of the Bacteriophage T4 recombination mediator protein UvsY, Lattice Type IV
Descriptor:	Recombination protein uvsY
Authors:	Gajewski, S, White, S.W.
Deposit date:	2015-05-19
Release date:	2016-03-02
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (4.2 Å)
Cite:	Structure and mechanism of the phage T4 recombination mediator protein UvsY. Proc.Natl.Acad.Sci.USA, 113, 2016

2EKE

Structure of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p: conservation of a noncovalent Ubiquitin-like protein-E2 complex as a platform for selective interactions within a SUMO pathway
Descriptor:	SUMO-conjugating enzyme UBC9, Ubiquitin-like protein SMT3
Authors:	Duda, D.M, Schulman, B.A.
Deposit date:	2007-03-23
Release date:	2007-05-29
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structure of a SUMO-binding-motif Mimic Bound to Smt3p-Ubc9p: Conservation of a Non-covalent Ubiquitin-like Protein-E2 Complex as a Platform for Selective Interactions within a SUMO Pathway J.Mol.Biol., 369, 2007

6D74

Direct Activation of the Executioner Domain of MLKL by a Select Repertoire of Inositol Phosphates
Descriptor:	Mixed lineage kinase domain-like protein
Authors:	Royappa, G.C, McNamara, D.E, Moldoveanu, T.
Deposit date:	2018-04-24
Release date:	2019-05-15
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites. Cell Chem Biol, 26, 2019

8EBM

Structure of KLHDC2 substrate binding domain bound to KLHDC2's C-degron mimic
Descriptor:	ASN-GLN-ARG-PHE-GLY-SER-ASN-ASN-THR-SER-GLY-SER, Kelch domain-containing protein 2
Authors:	Scott, D.C, Schulman, B.A.
Deposit date:	2022-08-31
Release date:	2023-02-22
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.58 Å)
Cite:	E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Mol.Cell, 83, 2023

8EBN

Structure of KLHDC2-EloB/C tetrameric assembly
Descriptor:	Elongin-B, Elongin-C, Kelch domain-containing protein 2
Authors:	Scott, D.C, Schulman, B.A.
Deposit date:	2022-08-31
Release date:	2023-02-22
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Mol.Cell, 83, 2023

8EBL

Structure of KLHDC2 substrate binding domain bound to C-degron from EPHB2
Descriptor:	GLU-ASP-SER-HIS-LYS-GLU-SER-ASN-ASP-CYS-SER-CYS-GLY-GLY, Kelch domain-containing protein 2
Authors:	Scott, D.C, Schulman, B.A.
Deposit date:	2022-08-31
Release date:	2023-02-22
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.37 Å)
Cite:	E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. Mol.Cell, 83, 2023

6NXD

TYPE I L-ASPARAGINASE FROM ESCHERICHIA COLI IN COMPLEX WITH CITRATE AT PH 4
Descriptor:	1,2-ETHANEDIOL, ASPARAGINE, CHLORIDE ION, ...
Authors:	Lubkowski, J, Wlodawer, A.
Deposit date:	2019-02-08
Release date:	2019-08-07
Last modified:	2020-01-15
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Opportunistic complexes of E. coli L-asparaginases with citrate anions. Sci Rep, 9, 2019

6NXC

ECAI(T162A) MUTANT IN COMPLEX WITH CITRATE AT PH 4
Descriptor:	1,2-ETHANEDIOL, ASPARAGINE, CHLORIDE ION, ...
Authors:	Lubkowski, J, Wlodawer, A.
Deposit date:	2019-02-08
Release date:	2019-08-07
Last modified:	2019-11-20
Method:	X-RAY DIFFRACTION (1.74 Å)
Cite:	Opportunistic complexes of E. coli L-asparaginases with citrate anions. Sci Rep, 9, 2019

4HNJ

Crystallographic structure of BCL-xL domain-swapped dimer in complex with PUMA BH3 peptide at 2.9A resolution
Descriptor:	Bcl-2-binding component 3, Bcl-2-like protein 1
Authors:	Fisher, J.C, Yun, M.K, White, S.W.
Deposit date:	2012-10-19
Release date:	2013-01-23
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013

4KBL

Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism
Descriptor:	E3 ubiquitin-protein ligase ARIH1, ZINC ION
Authors:	Duda, D.M, Olszewski, J.L, Schulman, B.A.
Deposit date:	2013-04-23
Release date:	2013-05-29
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (3.3 Å)
Cite:	Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013

4KC9

Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism
Descriptor:	E3 ubiquitin-protein ligase ARIH1, ZINC ION
Authors:	Duda, D.M, Olszewski, J.L, Schulman, B.A.
Deposit date:	2013-04-24
Release date:	2013-05-29
Last modified:	2013-07-03
Method:	X-RAY DIFFRACTION (3.603 Å)
Cite:	Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism. Structure, 21, 2013

2LK4

Structural and mechanistic insights into the interaction between PAT Pyk2 and Paxillin LD motif
Descriptor:	Protein-tyrosine kinase 2-beta
Authors:	Vanarotti, M, Miller, D, Guibao, C, Zheng, J.
Deposit date:	2011-10-04
Release date:	2012-10-10
Last modified:	2024-05-01
Method:	SOLUTION NMR
Cite:	Structural and Mechanistic Insights into the Interaction between Pyk2 and Paxillin LD Motifs. J.Mol.Biol., 426, 2014

2M5B

The NMR structure of the BID-BAK complex
Descriptor:	Bcl-2 homologous antagonist/killer, human_BID_BH3_SAHB
Authors:	Moldoveanu, T, Grace, C.R, Kriwacki, R.W, Green, D.R.
Deposit date:	2013-02-19
Release date:	2013-04-17
Last modified:	2023-11-15
Method:	SOLUTION NMR
Cite:	BID-induced structural changes in BAK promote apoptosis. Nat.Struct.Mol.Biol., 20, 2013

7N00

Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha
Descriptor:	ALK and LTK ligand 2, ALK tyrosine kinase receptor
Authors:	Reshetnyak, A.V, Myasnikov, A.G, Rossi, P, Miller, D.J, Kalodimos, C.G.
Deposit date:	2021-05-24
Release date:	2021-11-24
Last modified:	2021-12-15
Method:	ELECTRON MICROSCOPY (2.27 Å)
Cite:	Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 600, 2021

7MZY

Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986
Descriptor:	ACETATE ION, ALK tyrosine kinase receptor
Authors:	Reshetnyak, A.V, Sowaileh, M, Miller, D.J, Rossi, P, Myasnikov, A.G, Kalodimos, C.G.
Deposit date:	2021-05-24
Release date:	2021-11-24
Last modified:	2021-12-15
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 600, 2021

7MZZ

AUGbeta - FAM150A - ALKL1 60-128
Descriptor:	ALK and LTK ligand 1
Authors:	Rossi, P, Sowaileh, M, Reshetnyak, A.V, Kalodimos, C.G.
Deposit date:	2021-05-24
Release date:	2021-11-24
Last modified:	2023-06-14
Method:	SOLUTION NMR
Cite:	Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 600, 2021

7MZW

Anaplastic lymphoma kinase (ALK) extracellular ligand binding region 673-1025
Descriptor:	ALK tyrosine kinase receptor
Authors:	Rossi, P, Sowaileh, M, Reshetnyak, A.V, Kalodimos, C.G.
Deposit date:	2021-05-24
Release date:	2021-12-08
Last modified:	2021-12-15
Method:	SOLUTION NMR
Cite:	Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 600, 2021

7MZX

AUGalpha - FAM150B - ALKL2 77-152
Descriptor:	ALK and LTK ligand 2
Authors:	Rossi, P, Sowaileh, M, Reshetnyak, A.V, Kalodimos, C.G.
Deposit date:	2021-05-24
Release date:	2021-11-24
Last modified:	2023-06-14
Method:	SOLUTION NMR
Cite:	Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 600, 2021

2M04

Solution structure of BCL-xL in complex with PUMA BH3 peptide
Descriptor:	Bcl-2-binding component 3, Bcl-2-like protein 1
Authors:	Viacava Follis, A, Royappa, G, Kriwacki, R.W.
Deposit date:	2012-10-19
Release date:	2013-01-30
Last modified:	2024-05-01
Method:	SOLUTION NMR
Cite:	PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013

2M03

Solution structure of BCL-xL determined with selective isotope labelling of I,L,V sidechains
Descriptor:	Bcl-2-like protein 1
Authors:	Viacava Follis, A, Royappa, G, Kriwacki, R.W.
Deposit date:	2012-10-19
Release date:	2013-01-30
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nat.Chem.Biol., 9, 2013

4XEF

Pyk2-FAT complexed with Leupaxin LD motif LD1
Descriptor:	20-mer peptide containing LD1 motif of leupaxin, Protein-tyrosine kinase 2-beta
Authors:	Miller, D.J.
Deposit date:	2014-12-23
Release date:	2015-12-23
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats. Biochemistry, 55, 2016

4XEV

Fusion of Pyk2-FAT domain with Leupaxin LD1 motif, complexed with Leupaxin LD4 peptide
Descriptor:	19-mer peptide containing Leupaxin LD4 motif, Fusion protein of Protein-tyrosine kinase 2-beta FAT domain and Leupaxin LD1 motif
Authors:	Miller, D.J.
Deposit date:	2014-12-24
Release date:	2015-12-30
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.0073 Å)
Cite:	Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats. Biochemistry, 55, 2016

4YWM

Pyrococcus furiosus MCM N-terminal domain beta-turn triple mutant pentameric ring
Descriptor:	Cell division control protein 21, SULFATE ION, ZINC ION
Authors:	Froelich, C.A, Enemark, E.J.
Deposit date:	2015-03-20
Release date:	2015-09-23
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	MCM ring hexamerization is a prerequisite for DNA-binding. Nucleic Acids Res., 43, 2015

4YWK

Pyrococcus furiosus MCM N-terminal domain with Zinc-binding subdomain B deleted
Descriptor:	Cell division control protein 21
Authors:	Froelich, C.A, Enemark, E.J.
Deposit date:	2015-03-20
Release date:	2015-09-23
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	MCM ring hexamerization is a prerequisite for DNA-binding. Nucleic Acids Res., 43, 2015

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