8BD5
 
 | | Cas12k-sgRNA-dsDNA-S15-TniQ-TnsC transposon recruitment complex | | Descriptor: | 30S ribosomal protein S15, ADENOSINE-5'-TRIPHOSPHATE, DNA non-target strand, ... | | Authors: | Schmitz, M, Querques, I, Oberli, S, Chanez, C, Jinek, M. | | Deposit date: | 2022-10-18 | | Release date: | 2022-12-28 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex.
Cell, 185, 2022
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8BD4
 | | TniQ-capped Tns-ATP-dsDNA complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*C)-3'), MAGNESIUM ION, ... | | Authors: | Querques, I, Schmitz, M, Oberli, S, Chanez, C, Jinek, M. | | Deposit date: | 2022-10-18 | | Release date: | 2022-12-28 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex.
Cell, 185, 2022
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8BD6
 | | Cas12k-sgRNA-dsDNA-TnsC non-productive complex. | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cas12k, DNA, ... | | Authors: | Schmitz, M, Querques, I, Oberli, S, Chanez, C, Jinek, M. | | Deposit date: | 2022-10-18 | | Release date: | 2022-12-28 | | Last modified: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex.
Cell, 185, 2022
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5AF2
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7OXD
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7P3A
 | | N-terminal domain of CGI-99 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ISOPROPYL ALCOHOL, ... | | Authors: | Kroupova, A, Jinek, M. | | Deposit date: | 2021-07-07 | | Release date: | 2021-12-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Molecular architecture of the human tRNA ligase complex.
Elife, 10, 2021
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7P3B
 | | Human RNA ligase RTCB in complex with GMP and Co(II) | | Descriptor: | ACETATE ION, COBALT (II) ION, FORMIC ACID, ... | | Authors: | Kroupova, A, Ackle, F, Jinek, M. | | Deposit date: | 2021-07-07 | | Release date: | 2021-12-22 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular architecture of the human tRNA ligase complex.
Elife, 10, 2021
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8R3Z
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8QLP
 | | CryoEM structure of the RNA/DNA bound SPARTA (BabAgo/TIR-APAZ) tetrameric complex | | Descriptor: | DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*AP*TP*TP*AP*GP*AP*GP*CP*CP*GP*TP*C)-3'), MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*AP*GP*U)-3'), ... | | Authors: | Finocchio, G, Koopal, B, Potocnik, A, Heijstek, C, Jinek, M, Swarts, D. | | Deposit date: | 2023-09-20 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA.
Nucleic Acids Res., 52, 2024
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8QLO
 | | CryoEM structure of the apo SPARTA (BabAgo/TIR-APAZ) complex | | Descriptor: | Short prokaryotic Argonaute, Toll/interleukin-1 receptor domain-containing protein | | Authors: | Finocchio, G, Koopal, B, Potocnik, A, Heijstek, C, Jinek, M, Swarts, D. | | Deposit date: | 2023-09-20 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.57 Å) | | Cite: | Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA.
Nucleic Acids Res., 52, 2024
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5NFV
 | | Crystal structure of catalytically inactive FnCas12 mutant bound to an R-loop structure containing a pre-crRNA mimic and full-length DNA target | | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CRISPR-associated endonuclease Cpf1, DNA non-target strand, ... | | Authors: | Swarts, D.C, van der Oost, J, Jinek, M. | | Deposit date: | 2017-03-16 | | Release date: | 2017-06-14 | | Method: | X-RAY DIFFRACTION (2.501 Å) | | Cite: | Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.
Mol. Cell, 66, 2017
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5NG6
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5L6D
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5L6E
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5FQ5
 | | Crystal structure of Cas9-sgRNA-DNA complex solved by native SAD phasing | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | Authors: | Olieric, V, Weinert, T, Finke, A, Anders, C, Jinek, M, Wang, M. | | Deposit date: | 2015-12-07 | | Release date: | 2016-03-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.136 Å) | | Cite: | Data-Collection Strategy for Challenging Native Sad Phasing.
Acta Crystallogr.,Sect.D, 72, 2016
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4UN5
 | | Crystal structure of Cas9 bound to PAM-containing DNA target containing mismatches at positions 1-3 | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | Authors: | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | | Deposit date: | 2014-05-25 | | Release date: | 2014-07-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014
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4UN4
 | | Crystal structure of Cas9 bound to PAM-containing DNA target with mismatches at positions 1-2 | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | Authors: | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | | Deposit date: | 2014-05-25 | | Release date: | 2014-07-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.371 Å) | | Cite: | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014
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4UN3
 | | Crystal structure of Cas9 bound to PAM-containing DNA target | | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | | Authors: | Anders, C, Niewoehner, O, Duerst, A, Jinek, M. | | Deposit date: | 2014-05-25 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.593 Å) | | Cite: | Structural Basis of Pam-Dependent Target DNA Recognition by the Cas9 Endonuclease
Nature, 513, 2014
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6FUW
 | | Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution | | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3'), ... | | Authors: | Clerici, M, Faini, M, Jinek, M. | | Deposit date: | 2018-02-28 | | Release date: | 2018-03-21 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
Nat. Struct. Mol. Biol., 25, 2018
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3ICQ
 | | Karyopherin nuclear state | | Descriptor: | Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | | Deposit date: | 2009-07-18 | | Release date: | 2009-08-25 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009
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3IBV
 | | Karyopherin cytosolic state | | Descriptor: | CALCIUM ION, Exportin-T | | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | | Deposit date: | 2009-07-17 | | Release date: | 2009-08-25 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states
Nature, 461, 2009
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6F9N
 | | CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX | | Descriptor: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | | Authors: | Clerici, M, Jinek, M. | | Deposit date: | 2017-12-14 | | Release date: | 2018-01-03 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
Elife, 6, 2017
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6RW0
 | | Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase | | Descriptor: | GLYCEROL, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Kroupova, A, Jinek, M. | | Deposit date: | 2019-06-03 | | Release date: | 2020-05-20 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Science, 369, 2020
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6RVZ
 | | Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate | | Descriptor: | ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ... | | Authors: | Kroupova, A, Jinek, M. | | Deposit date: | 2019-06-03 | | Release date: | 2020-05-20 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity.
Science, 369, 2020
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6TUG
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