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4JDS
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BU of 4jds by Molmil
SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
Descriptor: Histone-lysine N-methyltransferase SETD7, N-[(2R)-3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl]-8-fluoro-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, S-ADENOSYLMETHIONINE, ...
Authors:Dong, A, Wu, H, Zeng, H, Park, H, El Bakkouri, M, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2013-02-25
Release date:2013-03-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:SETD7 in complex with inhibitor PF-5426 and S-adenosyl-methionine
to be published
4K7Z
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BU of 4k7z by Molmil
Crystal structure of the C136(42)A/C141(47)A double mutant of Tn501 MerA in complex with NADP and Hg2+
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, MERCURY (II) ION, ...
Authors:Dong, A, Falkowaski, M, Malone, M, Miller, S.M, Pai, E.F.
Deposit date:2013-04-17
Release date:2013-05-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the C136(42)A/C141(47)A double mutant of Tn501 MerA in complex with NADP and Hg2+
To be Published
3RAY
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BU of 3ray by Molmil
Crystal structure of Methyltransferase domain of human PR domain-containing protein 11
Descriptor: CHLORIDE ION, PR domain-containing protein 11, SODIUM ION, ...
Authors:Dong, A, Zeng, H, Loppnau, P, Walker, J.R, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2011-03-28
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Crystal structure of Methyltransferase domain of human PR domain-containing protein 11
To be Published
4MI0
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BU of 4mi0 by Molmil
Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2)
Descriptor: Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION
Authors:Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2013-08-30
Release date:2013-09-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
Plos One, 8, 2013
3SMR
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BU of 3smr by Molmil
Crystal structure of human WD repeat domain 5 with compound
Descriptor: 1,2-ETHANEDIOL, 2-chloro-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ...
Authors:Dong, A, Dombrovski, L, Wasney, G.A, Tempel, W, Senisterra, G, Bolshan, Y, Smil, D, Nguyen, K.T, Hajian, T, Poda, G, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Brown, P.J, Schapira, M, Arrowsmith, C.H, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2011-06-28
Release date:2011-08-31
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem. J., 449, 2013
3SMT
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BU of 3smt by Molmil
Crystal structure of human SET domain-containing protein3
Descriptor: ACETATE ION, ARSENIC, Histone-lysine N-methyltransferase setd3, ...
Authors:Dong, A, Zeng, H, Walker, J.R, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2011-06-28
Release date:2011-07-20
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystal structure of human SET domain-containing protein3
To be Published
3UR4
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BU of 3ur4 by Molmil
Crystal structure of human WD repeat domain 5 with compound
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, SULFATE ION, ...
Authors:Dong, A, Dombrovski, L, Senisterra, G, Wernimont, A, Wasney, G.A, Allali Hassani, A, Nguyen, K.T, Smil, D, Bolshan, Y, Hajian, T, Poda, G, Chau, I, Al-Awar, R, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2011-11-21
Release date:2011-12-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem. J., 449, 2013
3TUG
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BU of 3tug by Molmil
Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Itchy homolog, UNKNOWN ATOM OR ION
Authors:Dong, A, Dobrovetsky, E, Xue, S, Butler, C, Wernimont, A, Walker, J.R, Tempel, W, Dhe-Paganon, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2011-09-16
Release date:2011-10-12
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase
To be Published
4QQE
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BU of 4qqe by Molmil
Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, N-[2-(4-methylpiperazin-1-yl)-5-(quinolin-3-yl)phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ...
Authors:Dong, A, Dombrovski, L, Wernimont, A, Smil, D, Getlik, M, Senisterra, G, Poda, G, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2014-06-27
Release date:2014-07-30
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345
To be Published
4QT6
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BU of 4qt6 by Molmil
Crystal structure of the SPRY domain of human HERC1
Descriptor: FORMAMIDE, Probable E3 ubiquitin-protein ligase HERC1, UNKNOWN ATOM OR ION
Authors:Dong, A, Hu, J, Guan, X, Wernimont, A, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2014-07-07
Release date:2015-01-07
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Crystal structure of the SPRY domain of human HERC1
To be Published
5KE3
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BU of 5ke3 by Molmil
Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a
Descriptor: (S)-N-(furan-2-ylmethyl)-1-(1,2,3,4-tetrahydroisoquinoline-3-carbonyl)piperidine-4-carboxamide, BETA-MERCAPTOETHANOL, Histone-lysine N-methyltransferase SETDB1, ...
Authors:Dong, A, Iqbal, A, Mader, P, Dobrovetsky, E, Ferreira de Freitas, R, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Schapira, M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2016-06-09
Release date:2016-08-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a
to be published
3DLJ
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BU of 3dlj by Molmil
Crystal structure of human carnosine dipeptidase 1
Descriptor: Beta-Ala-His dipeptidase, SULFATE ION, UNKNOWN ATOM OR ION, ...
Authors:Dong, A, Dobrovetsky, E, Seitova, A, He, H, Tempel, W, Kozieradzki, I, Arrowsmith, C.H, Weigelt, J, Bountra, C, Edwards, A.M, Bochkarev, A, Cossar, D, Structural Genomics Consortium (SGC)
Deposit date:2008-06-27
Release date:2008-08-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of human carnosine dipeptidase 1.
To be Published
5KE2
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BU of 5ke2 by Molmil
Crystal structure of SETDB1 Tudor domain in complex with inhibitor XST06472A
Descriptor: (3~{S})-~{N}-~{tert}-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETDB1, ...
Authors:Dong, A, Iqbal, A, Mader, P, Dobrovetsky, E, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC)
Deposit date:2016-06-09
Release date:2016-07-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal structure of SETDB1 Tudor domain in complex with inhibitor xst06472a
to be published
5HZM
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BU of 5hzm by Molmil
Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae)
Descriptor: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, UNKNOWN ATOM OR ION
Authors:DONG, A, ZENG, H, WALKER, J.R, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, MIN, J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2016-02-02
Release date:2016-02-17
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
4Z02
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BU of 4z02 by Molmil
Crystal structure of BRD1 in complex with Isoquinoline-3-carboxylic acid
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 1, UNKNOWN ATOM OR ION, ...
Authors:DONG, A, IQBAL, A, WALKER, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, Structural Genomics Consortium (SGC)
Deposit date:2015-03-25
Release date:2015-04-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structure of BRD1 incomplex with Isoquinoline-3-carboxylic acid
to be published
5C5C
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BU of 5c5c by Molmil
Human metabotropic glutamate receptor 7, extracellular ligand binding domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ...
Authors:Dong, A, Dobrovetsky, E, Hutchinson, A, Tempel, W, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
Deposit date:2015-06-19
Release date:2015-07-15
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.862 Å)
Cite:Human metabotropic glutamate receptor 7, extracellular ligand binding domain
to be published
5TEY
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BU of 5tey by Molmil
Human METTL3-METTL14 complex
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ...
Authors:DONG, A, ZENG, H, LI, Y, TEMPEL, W, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
Deposit date:2016-09-23
Release date:2016-11-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human METTL3-METTL14 complex
to be published
3K5K
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BU of 3k5k by Molmil
Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone Lysine Methyltransferase, G9a
Descriptor: 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine, CHLORIDE ION, Histone-lysine N-methyltransferase, ...
Authors:Dong, A, Wasney, G.A, Liu, F, Chen, X, Allali-Hassani, A, Senisterra, G, Chau, I, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Frye, S.V, Bochkarev, A, Brown, P.J, Jin, J, Vedadi, M, Structural Genomics Consortium (SGC)
Deposit date:2009-10-07
Release date:2009-11-10
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
J.Med.Chem., 52, 2009
3CKK
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BU of 3ckk by Molmil
Crystal structure of human methyltransferase-like protein 1
Descriptor: GLYCEROL, S-ADENOSYLMETHIONINE, tRNA (guanine-N(7)-)-methyltransferase
Authors:Dong, A, Zeng, H, Dobrovetsky, E, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Wu, H, Structural Genomics Consortium (SGC)
Deposit date:2008-03-16
Release date:2008-04-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of human methyltransferase-like protein 1.
To be Published
3FVY
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BU of 3fvy by Molmil
Crystal structure of human Dipeptidyl Peptidase III
Descriptor: CHLORIDE ION, Dipeptidyl-peptidase 3, MAGNESIUM ION, ...
Authors:Dong, A, Dobrovetsky, E, Seitova, A, Duncan, B, Crombet, L, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bochkarev, A, Cossar, D, Structural Genomics Consortium (SGC)
Deposit date:2009-01-16
Release date:2009-02-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.
Proc.Natl.Acad.Sci.USA, 109, 2012
3BFX
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BU of 3bfx by Molmil
Crystal structure of human sulfotransferase SULT1C1 in complex with PAP
Descriptor: ADENOSINE-3'-5'-DIPHOSPHATE, Sulfotransferase 1C2
Authors:Dong, A, Dombrovski, L, Loppnau, P, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2007-11-23
Release date:2007-12-04
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Human Sulfotransferases Sult1B1 and Sult1C1 Complexed with the Cofactor Product Adenosine-3'-5'-Diphosphate (Pap).
Proteins, 64, 2006
2NPM
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BU of 2npm by Molmil
crystal structure of Cryptosporidium parvum 14-3-3 protein in complex with peptide
Descriptor: 14-3-3 domain containing protein, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
Authors:Dong, A, Lew, J, Wasney, G, Ren, H, Lin, L, Hassanali, A, Qiu, W, Zhao, Y, Doyle, D, Vedadi, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC)
Deposit date:2006-10-27
Release date:2006-11-07
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Characterization of 14-3-3 proteins from Cryptosporidium parvum.
Plos One, 6, 2011
3MAV
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BU of 3mav by Molmil
Crystal structure of Plasmodium vivax putative farnesyl pyrophosphate synthase (Pv092040)
Descriptor: Farnesyl pyrophosphate synthase, SULFATE ION
Authors:Dong, A, Dunford, J, Lew, J, Wernimont, A.K, Ren, H, Zhao, Y, Koeieradzki, I, Opperman, U, Sundstrom, M, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC)
Deposit date:2010-03-24
Release date:2010-04-14
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
J.Biol.Chem., 286, 2011
4JHC
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BU of 4jhc by Molmil
Crystal structure of the uncharacterized Maf protein YceF from E. coli
Descriptor: GLYCEROL, Maf-like protein YceF, UNKNOWN ATOM OR ION
Authors:Dong, A, Xu, X, Cui, H, Tchigvintsev, A, Flick, R, Brown, G, Popovic, A, Yakunin, A.F, Savchenko, A.
Deposit date:2013-03-04
Release date:2013-03-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides.
Chem.Biol., 20, 2013
2NYU
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BU of 2nyu by Molmil
Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with S-adenosylmethionine
Descriptor: Putative ribosomal RNA methyltransferase 2, S-ADENOSYLMETHIONINE
Authors:Dong, A, Wu, H, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
Deposit date:2006-11-21
Release date:2006-12-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:The Crystal Structure of Human FtsJ homolog 2 (E.coli) protein in complex with AdoMet
To be Published

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