5KE2

Crystal structure of SETDB1 Tudor domain in complex with inhibitor XST06472A

Summary for 5KE2

• Entry DOI: 10.2210/pdb5ke2/pdb
• Descriptor: Histone-lysine N-methyltransferase SETDB1, (3~{S})-~{N}-~{tert}-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: setdb1, tudor domain, structural genomics, structural genomics consortium, sgc, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q15047
• Total number of polymer chains: 1
• Total formula weight: 25820.59

Authors

Dong, A.,Iqbal, A.,Mader, P.,Dobrovetsky, E.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2016-06-09, release date: 2016-07-13, Last modification date: 2023-09-27)

• Primary citation: Iqbal, A.,Mader, P.,Dong, A.,Dobrovetsky, E.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.; Crystal structure of SETDB1 Tudor domain in complex with inhibitor xst06472a; to be published,

Experimental method

X-RAY DIFFRACTION (1.56 Å)