5KE3

Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a

Summary for 5KE3

• Entry DOI: 10.2210/pdb5ke3/pdb
• Descriptor: Histone-lysine N-methyltransferase SETDB1, (S)-N-(furan-2-ylmethyl)-1-(1,2,3,4-tetrahydroisoquinoline-3-carbonyl)piperidine-4-carboxamide, BETA-MERCAPTOETHANOL, ... (6 entities in total)
• Functional Keywords: setdb1, tudor domain, structural genomics, structural genomics consortium, sgc, methyl-lysine, inhibitor, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q15047
• Total number of polymer chains: 1
• Total formula weight: 25717.58

Authors

Dong, A.,Iqbal, A.,Mader, P.,Dobrovetsky, E.,Ferreira de Freitas, R.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Schapira, M.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2016-06-09, release date: 2016-08-03, Last modification date: 2023-09-27)

• Primary citation: Iqbal, A.,Mader, P.,Dong, A.,Dobrovetsky, E.,Ferreira de Freitas, R.,Walker, J.R.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Schapira, M.,Brown, P.J.; Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a; to be published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)