5KE3
Crystal structure of SETDB1 Tudor domain in complex with fragment MRT0181a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase SETDB1 | polymer | 213 | 24887.8 | 1 | UniProt (Q15047) Pfam (PF18300) Pfam (PF18359) Pfam (PF18358) | Homo sapiens (Human) | ERG-associated protein with SET domain,ESET,Histone H3-K9 methyltransferase 4,H3-K9-HMTase 4,Lysine N-methyltransferase 1E,SET domain bifurcated 1 |
| 2 | B (A) | (S)-N-(furan-2-ylmethyl)-1-(1,2,3,4-tetrahydroisoquinoline-3-carbonyl)piperidine-4-carboxamide | non-polymer | 367.4 | 1 | Chemie (6S5) | |||
| 3 | C (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 4 | D, E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | H, I, J, K, L... (A) | UNKNOWN ATOM OR ION | non-polymer | 10 | Chemie (UNX) | ||||
| 6 | R (A) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 196 - 402 (UniProt: Q15047)
| PDB | External Database | Details |
|---|---|---|
| Glu 190 | - | expression tag |
| Asn 191 | - | expression tag |
| Leu 192 | - | expression tag |
| Tyr 193 | - | expression tag |
| Phe 194 | - | expression tag |
| Gln 195 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24887.8 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 829.8 | |
| All* | Total formula weight | 25717.6 |
