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7N9C
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BU of 7n9c by Molmil
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB95
Descriptor: Nanobody NB95, Spike glycoprotein
Authors:Sun, D, Zhang, C, Shi, Y.
Deposit date:2021-06-17
Release date:2021-08-04
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021
7N9E
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BU of 7n9e by Molmil
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB34
Descriptor: Nb34 nanobody, Spike glycoprotein
Authors:Sun, D, Zhang, C, Shi, Y.
Deposit date:2021-06-17
Release date:2021-08-04
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021
7N9B
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BU of 7n9b by Molmil
Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes-CovS with NB21
Descriptor: NB21 Nanobody, Spike glycoprotein
Authors:Sun, D, Zhang, C, Shi, Y.
Deposit date:2021-06-17
Release date:2021-08-04
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021
7FI4
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BU of 7fi4 by Molmil
Structure of AcrIF13
Descriptor: AcrIF13
Authors:Feng, Y, Gao, T.
Deposit date:2021-07-30
Release date:2022-07-06
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Mechanistic insights into the inhibition of the CRISPR-Cas surveillance complex by anti-CRISPR protein AcrIF13.
J.Biol.Chem., 298, 2022
2WW3
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BU of 2ww3 by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482 in complex with thiomannobioside
Descriptor: CALCIUM ION, GLYCEROL, PUTATIVE ALPHA-1,2-MANNOSIDASE, ...
Authors:Suits, M.D.L, Zhu, Y, Thompson, A.J, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2010-01-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanistic Insights Into a Ca(2+)-Dependent Family of Alpha-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
2WVY
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BU of 2wvy by Molmil
STRUCTURE OF THE FAMILY GH92 INVERTING MANNOSIDASE BT2199 FROM BACTEROIDES THETAIOTAOMICRON VPI-5482
Descriptor: ALPHA-1,2-MANNOSIDASE
Authors:Suits, M.D.L, Zhu, Y, Thompson, A, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-11-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
8K4F
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BU of 8k4f by Molmil
DHODH in complex with compound A0
Descriptor: 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine, 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, ACETATE ION, ...
Authors:Jian, L, Sun, Q.
Deposit date:2023-07-18
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease.
J.Med.Chem., 66, 2023
2WW2
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BU of 2ww2 by Molmil
Structure of the Family GH92 Inverting Mannosidase BT2199 from Bacteroides thetaiotaomicron VPI-5482
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, ALPHA-1,2-MANNOSIDASE, ...
Authors:Suits, M.D.L, Zhu, Y, Thompson, A, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-12-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
2WVX
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BU of 2wvx by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482
Descriptor: CALCIUM ION, GLYCEROL, PUTATIVE ALPHA-1,2-MANNOSIDASE
Authors:Suits, M.D.L, Zhu, Y, Thompson, A, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
2WW1
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BU of 2ww1 by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482 in complex with Thiomannobioside
Descriptor: PUTATIVE ALPHA-1,2-MANNOSIDASE, alpha-D-mannopyranose-(1-2)-methyl 2-thio-alpha-D-mannopyranoside
Authors:Suits, M.D.L, Zhu, Y, Thompson, A, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-12-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
7N9T
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BU of 7n9t by Molmil
CryoEM structure of SARS-CoV-2 Spike in complex with Nb17
Descriptor: Nanobody Nb17, Spike glycoprotein
Authors:Huang, W, Taylor, D.
Deposit date:2021-06-18
Release date:2021-08-11
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021
4GVJ
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BU of 4gvj by Molmil
Tyk2 (JH1) in complex with adenosine di-phosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Non-receptor tyrosine-protein kinase TYK2
Authors:Liang, J, Abbema, A.V, Bao, L, Barrett, K, Beresini, M, Berezhkovskiy, L, Blair, W, Chang, C, Driscoll, J, Eigenbrot, C, Ghilardi, N, Gibbons, P, Halladay, J, Johnson, A, Kohli, P.B, Lai, Y, Liimatta, M, Mantik, P, Menghrajani, K, Murray, J, Sambrone, A, Shao, Y, Shia, S, Shin, Y, Smith, J, Sohn, S, Stanley, M, Tsui, V, Ultsch, M, Wu, L, Zhang, B, Magnuson, S.
Deposit date:2012-08-30
Release date:2013-08-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Lead identification of novel and selective TYK2 inhibitors.
Eur.J.Med.Chem., 67, 2013
2WW0
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BU of 2ww0 by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482
Descriptor: 1S-8AB-OCTAHYDRO-INDOLIZIDINE-1A,2A,8B-TRIOL, CALCIUM ION, GLYCEROL, ...
Authors:Suits, M.D.L, Thompson, A, Zhu, Y, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-12-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
2WVZ
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BU of 2wvz by Molmil
Structure of the Family GH92 Inverting Mannosidase BT3990 from Bacteroides thetaiotaomicron VPI-5482
Descriptor: CALCIUM ION, GLYCEROL, KIFUNENSINE, ...
Authors:Suits, M.D.L, Zhu, Y, Thompson, A, Gilbert, H.J, Davies, G.J.
Deposit date:2009-10-21
Release date:2009-12-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanistic Insights Into a Ca2+-Dependent Family of A-Mannosidases in a Human Gut Symbiont.
Nat.Chem.Biol., 6, 2010
7MEJ
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BU of 7mej by Molmil
CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb21 and Nb36
Descriptor: Nanobody Nb21, Nanobody Nb36, Spike protein S1
Authors:Huang, W, Taylor, D.J.
Deposit date:2021-04-06
Release date:2021-08-11
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021
7MDW
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BU of 7mdw by Molmil
CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb21 and Nb105
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, nanobody Nb105, ...
Authors:Huang, W, Taylor, D.J.
Deposit date:2021-04-06
Release date:2021-08-11
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021
7ME7
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BU of 7me7 by Molmil
CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb17 and Nb105
Descriptor: Nanobody Nb105, Nanobody Nb17, Spike protein S1
Authors:Huang, W, Taylor, D.J.
Deposit date:2021-04-06
Release date:2021-08-11
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes
Nat Commun, 12, 2021
7EQ2
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BU of 7eq2 by Molmil
Crystal structure of GDP-bound Rab1a-T75D
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, COBALT HEXAMMINE(III), ...
Authors:Cao, Y.L, Gu, D.D, Gao, S.
Deposit date:2021-04-28
Release date:2022-11-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55090284 Å)
Cite:Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis
Nat.Struct.Mol.Biol., 2024
4GJ2
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BU of 4gj2 by Molmil
Tyk2 (JH1) in complex with 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide
Descriptor: 2,6-dichloro-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Ultsch, M.H.
Deposit date:2012-08-09
Release date:2013-05-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors.
J.Med.Chem., 56, 2013
6WIG
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BU of 6wig by Molmil
Structure of STENOFOLIA Protein HD domain bound with DNA
Descriptor: DNA (5'-D(P*CP*TP*TP*GP*AP*AP*TP*AP*AP*AP*TP*CP*AP*TP*TP*AP*AP*TP*TP*TP*GP*C)-3'), DNA (5'-D(P*GP*CP*AP*AP*AP*TP*TP*AP*AP*TP*GP*AP*TP*TP*TP*AP*TP*TP*CP*AP*AP*G)-3'), STENOFOLIA
Authors:Deng, J, Peng, S, Pathak, P.
Deposit date:2020-04-09
Release date:2021-08-11
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the unique tetrameric STENOFOLIA homeodomain bound with target promoter DNA.
Acta Crystallogr D Struct Biol, 77, 2021
4GII
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BU of 4gii by Molmil
Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide
Descriptor: 2,6-dichloro-4-cyano-N-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Ultsch, M.H.
Deposit date:2012-08-08
Release date:2013-05-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors.
J.Med.Chem., 56, 2013
5H06
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BU of 5h06 by Molmil
Crystal structure of AmyP in complex with maltose
Descriptor: AmyP, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:He, C, Liu, Y.
Deposit date:2016-10-03
Release date:2017-08-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of a raw-starch-degrading bacterial alpha-amylase belonging to subfamily 37 of the glycoside hydrolase family GH13
Sci Rep, 7, 2017
5H05
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BU of 5h05 by Molmil
Crystal structure of AmyP E221Q in complex with MALTOTRIOSE
Descriptor: AmyP, CALCIUM ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:He, C, Liu, Y.
Deposit date:2016-10-03
Release date:2017-08-16
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of a raw-starch-degrading bacterial alpha-amylase belonging to subfamily 37 of the glycoside hydrolase family GH13
Sci Rep, 7, 2017
4GJ3
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BU of 4gj3 by Molmil
Tyk2 (JH1) in complex with 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide
Descriptor: 2,6-dichloro-4-cyano-N-[2-({[(1R,2R)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Ultsch, M.H.
Deposit date:2012-08-09
Release date:2013-05-29
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Lead Optimization of a 4-Aminopyridine Benzamide Scaffold To Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors.
J.Med.Chem., 56, 2013
8K6L
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BU of 8k6l by Molmil
Cryo-EM structure of human OATP1B1 in complex with DCF
Descriptor: 2',7'-bis(chloranyl)-3',6'-bis(oxidanyl)spiro[2-benzofuran-3,9'-xanthene]-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Shan, Z, Yang, X, Zhang, Y.
Deposit date:2023-07-25
Release date:2023-09-13
Last modified:2023-12-20
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.
Cell Res., 33, 2023

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