6O0J

M.tb MenD with ThDP and Inhibitor bound

6O0J の概要

• エントリーDOI: 10.2210/pdb6o0j/pdb
• 関連するPDBエントリー: 5ERX 5ERY 5ESD 5ESO 5ESS 5ESU 6O04 6O0G
• 分子名称: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, 1,4-dihydroxy-2-naphthoic acid, GLYCEROL, ... (8 entities in total)
• 機能のキーワード: menaquinone biosynthesis, thdp dependent, decarboxylation, c-c bond ligation, inhibitor complex, sephchc synthase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 242491.13

構造登録者

Johnston, J.M.,Bashiri, G.,Bulloch, E.M.M.,Jirgis, E.M.N.,Nigon, L.V.,Chuang, H.,Ho, N.A.T.,Baker, E.N. (登録日: 2019-02-16, 公開日: 2020-02-19, 最終更新日: 2023-10-11)

• 主引用文献: Bashiri, G.,Nigon, L.V.,Jirgis, E.N.M.,Ho, N.A.T.,Stanborough, T.,Dawes, S.S.,Baker, E.N.,Bulloch, E.M.M.,Johnston, J.M.; Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis.; J.Biol.Chem., 295:3759-3770, 2020; PubMed: 32029475; DOI: 10.1074/jbc.RA119.012158

実験手法

X-RAY DIFFRACTION (2.35 Å)