4ZZ3

Human GAR transformylase in complex with GAR and pemetrexed

Summary for 4ZZ3

Entry DOI	10.2210/pdb4zz3/pdb
Related	1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ1 4ZZ2
Descriptor	Trifunctional purine biosynthetic protein adenosine-3, N-{4-[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid, GLYCINAMIDE RIBONUCLEOTIDE, ... (4 entities in total)
Functional Keywords	gar transformylase, antifolate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	23519.69
Authors	Deis, S.M.,Dann III, C.E. (deposition date: 2015-05-22, release date: 2015-12-16, Last modification date: 2023-09-27)
Primary citation	Wang, L.,Wallace, A.,Raghavan, S.,Deis, S.M.,Wilson, M.R.,Yang, S.,Polin, L.,White, K.,Kushner, J.,Orr, S.,George, C.,O'Connor, C.,Hou, Z.,Mitchell-Ryan, S.,Dann, C.E.,Matherly, L.H.,Gangjee, A. 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors. J.Med.Chem., 58:6938-6959, 2015 Cited by PubMed: 26317331 DOI: 10.1021/acs.jmedchem.5b00801 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.504 Å)

Structure validation