4XBE

Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 gp41: crystals cryoprotected with sphingomyelin (02:0 SM (d18:1/2:0)).

Summary for 4XBE

Entry DOI	10.2210/pdb4xbe/pdb
Related	2FX7 4XAW 4XBG 4XBP 4XC1 4XC3 4XCC 4XCE 4XCF 4XCN 4XCY
Descriptor	4E10 FAB LIGHT CHAIN, 4E10 Fab heavy chain, PEPTIDE FRAGMENT OF HIV GLYCOPROTEIN (GP41) including the region 671-683 of the MPER, ... (5 entities in total)
Functional Keywords	hiv-1 gp41 mper, 4e10 fab, membrane lipid, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	49634.50
Authors	Irimia, A.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2014-12-16, release date: 2016-02-03, Last modification date: 2023-09-27)
Primary citation	Irimia, A.,Sarkar, A.,Stanfield, R.L.,Wilson, I.A. Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10. Immunity, 44:21-31, 2016 Cited by PubMed: 26777395 DOI: 10.1016/j.immuni.2015.12.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.756 Å)

Structure validation