4XCF
Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 gp41; crystals cryoprotected with phosphatidylcholine (03:0 PC)
Summary for 4XCF
| Entry DOI | 10.2210/pdb4xcf/pdb |
| Related | 4XAW 4XBE 4XBG 4XBP 4XC1 4XC3 4XCC 4XCE 4XCN 4XCY |
| Descriptor | 4E10 Fab light chain, 4E10 Fab heavy chain, MODIFIED FRAGMENT OF HIV-1 GLYCOPROTEIN (GP41) INCLUDING THE MPER REGION 671-683, ... (5 entities in total) |
| Functional Keywords | 4e10 fab anti hiv-1 gp41, phosphatidylcholine, membrane lipid, immune system |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 3 |
| Total formula weight | 51093.92 |
| Authors | Irimia, A.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2014-12-17, release date: 2016-02-03, Last modification date: 2023-09-27) |
| Primary citation | Irimia, A.,Sarkar, A.,Stanfield, R.L.,Wilson, I.A. Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10. Immunity, 44:21-31, 2016 Cited by PubMed: 26777395DOI: 10.1016/j.immuni.2015.12.001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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