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4XC3

Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 gp41; crystals cryoprotected with rac-glycerol 1-phosphate

Summary for 4XC3
Entry DOI10.2210/pdb4xc3/pdb
Related4XAW 4XBE 4XBG 4XBP 4XC1 4XCC 4XCE 4XCF 4XCN 4XCY
Descriptor4E10 Fab light chain, 4E10 Fab heavy chain, MODIFIED FRAGMENT OF HIV-1 GLYCOPROTEIN (GP41) INCLUDING THE MPER REGION 671-683, ... (6 entities in total)
Functional Keywordshiv-1 gp41 mper, 4e10 fab, membrane lipid, immune system
Biological sourceHomo sapiens
More
Total number of polymer chains3
Total formula weight50121.86
Authors
Irimia, A.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2014-12-17, release date: 2016-02-03, Last modification date: 2019-12-11)
Primary citationIrimia, A.,Sarkar, A.,Stanfield, R.L.,Wilson, I.A.
Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.
Immunity, 44:21-31, 2016
Cited by
PubMed: 26777395
DOI: 10.1016/j.immuni.2015.12.001
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.63 Å)
Structure validation

217705

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