4XC1
Crystal structure of human 4E10 Fab in complex with its peptide epitope on HIV-1 GP41: crystals cryoprotected with sn-Glycerol 3-phosphate
Summary for 4XC1
Entry DOI | 10.2210/pdb4xc1/pdb |
Related | 4XAW 4XBE 4XBG 4XBP 4XC3 4XCC 4XCE 4XCF 4XCN 4XCY |
Descriptor | 4E10 FAB LIGHT CHAIN, 4E10 FAB HEAVY CHAIN, MODIFIED FRAGMENT OF HIV-1 GLYCOPROTEIN (GP41) INCLUDING THE MPER REGION 671-683, ... (6 entities in total) |
Functional Keywords | hiv-1 gp41 mper, 4e10 fab, lipid membrane, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 50422.40 |
Authors | Irimia, A.,Stanfield, R.L.,Wilson, I.A. (deposition date: 2014-12-17, release date: 2016-02-03, Last modification date: 2023-11-15) |
Primary citation | Irimia, A.,Sarkar, A.,Stanfield, R.L.,Wilson, I.A. Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10. Immunity, 44:21-31, 2016 Cited by PubMed: 26777395DOI: 10.1016/j.immuni.2015.12.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
Download full validation report