4J5P
Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase
Summary for 4J5P
Entry DOI | 10.2210/pdb4j5p/pdb |
Related | 2WJ1 2WJ2 3K7F 3K83 3K84 3PR0 |
Descriptor | Fatty-acid amide hydrolase 1, (1S)-1-{5-[5-(bromomethyl)pyridin-2-yl]-1,3-oxazol-2-yl}-7-phenylheptan-1-ol, DI(HYDROXYETHYL)ETHER, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Rattus norvegicus (rat) |
Cellular location | Endoplasmic reticulum membrane ; Single-pass membrane protein : P97612 |
Total number of polymer chains | 2 |
Total formula weight | 127648.08 |
Authors | Otrubova, K.,Brown, M.,McCormick, M.S.,Han, G.W.,O'Neal, S.T.,Cravatt, B.F.,Stevens, R.C.,Lichtman, A.H.,Boger, D.L. (deposition date: 2013-02-08, release date: 2013-05-01, Last modification date: 2023-09-20) |
Primary citation | Otrubova, K.,Brown, M.,McCormick, M.S.,Han, G.W.,O'Neal, S.T.,Cravatt, B.F.,Stevens, R.C.,Lichtman, A.H.,Boger, D.L. Rational design of Fatty Acid amide hydrolase inhibitors that act by covalently bonding to two active site residues. J.Am.Chem.Soc., 135:6289-6299, 2013 Cited by PubMed: 23581831DOI: 10.1021/ja4014997 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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