4HYV
Pyruvate kinase (PYK) from Trypanosoma brucei in the presence of Magnesium, PEP and F26BP
Summary for 4HYV
Entry DOI | 10.2210/pdb4hyv/pdb |
Related | 3HQN 3HQO 3HQP 3HQQ 3PP7 3QV6 3QV7 3QV8 3SRK 4HYW |
Descriptor | Pyruvate kinase 1, MAGNESIUM ION, POTASSIUM ION, ... (8 entities in total) |
Functional Keywords | allosteric regulation, tetramer, pyruvate kinase, fructose-2, 6-diphosphate binding, phosphoenolpyruvate binding, cytosol, transferase |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 2 |
Total formula weight | 110349.79 |
Authors | Zhong, W.,Morgan, H.P.,McNae, I.W.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (deposition date: 2012-11-14, release date: 2013-09-11, Last modification date: 2024-02-28) |
Primary citation | Zhong, W.,Morgan, H.P.,McNae, I.W.,Michels, P.A.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. `In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase. Acta Crystallogr.,Sect.D, 69:1768-1779, 2013 Cited by PubMed: 23999300DOI: 10.1107/S0907444913013875 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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