3QV6

Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with acid blue 80.

Summary for 3QV6

Entry DOI	10.2210/pdb3qv6/pdb
Related	1PKL 3QV7 3QV8 3QV9
Descriptor	Pyruvate kinase, 3-({4-[(2,4-dimethyl-5-sulfophenyl)amino]-9,10-dioxo-9,10-dihydroanthracen-1-yl}amino)-2,4,6-trimethylbenzenesulfonic acid, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	pyruvate kinase, glycolysis, tim barrel, sugar kinase, adp/atp binding, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Leishmania mexicana
Total number of polymer chains	2
Total formula weight	110523.59
Authors	Morgan, H.P.,Auld, D.S.,McNae, I.W.,Nowicki, M.W.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (deposition date: 2011-02-25, release date: 2011-06-29, Last modification date: 2023-09-13)
Primary citation	Morgan, H.P.,McNae, I.W.,Nowicki, M.W.,Zhong, W.,Michels, P.A.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J.Biol.Chem., 286:31232-31240, 2011 Cited by PubMed: 21733839 DOI: 10.1074/jbc.M110.212613 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation