3QV7
Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with ponceau S and acid blue 25.
Summary for 3QV7
Entry DOI | 10.2210/pdb3qv7/pdb |
Related | 1PKL 3QV6 3QV8 3QV9 |
Descriptor | Pyruvate kinase, SULFATE ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | pyruvate kinase, glycolysis, tim barrel, sugar kinase, adp/atp binding, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Leishmania mexicana |
Total number of polymer chains | 4 |
Total formula weight | 222311.36 |
Authors | Morgan, H.P.,Auld, D.S.,McNae, I.W.,Nowicki, M.W.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (deposition date: 2011-02-25, release date: 2011-06-29, Last modification date: 2023-09-13) |
Primary citation | Morgan, H.P.,McNae, I.W.,Nowicki, M.W.,Zhong, W.,Michels, P.A.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J.Biol.Chem., 286:31232-31240, 2011 Cited by PubMed: 21733839DOI: 10.1074/jbc.M110.212613 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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