Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004743 | molecular_function | pyruvate kinase activity |
| A | 0006096 | biological_process | glycolytic process |
| A | 0006950 | biological_process | response to stress |
| A | 0030955 | molecular_function | potassium ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004743 | molecular_function | pyruvate kinase activity |
| B | 0006096 | biological_process | glycolytic process |
| B | 0006950 | biological_process | response to stress |
| B | 0030955 | molecular_function | potassium ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004743 | molecular_function | pyruvate kinase activity |
| C | 0006096 | biological_process | glycolytic process |
| C | 0006950 | biological_process | response to stress |
| C | 0030955 | molecular_function | potassium ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004743 | molecular_function | pyruvate kinase activity |
| D | 0006096 | biological_process | glycolytic process |
| D | 0006950 | biological_process | response to stress |
| D | 0030955 | molecular_function | potassium ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 499 |
| Chain | Residue |
| D | PRO87 |
| D | GLU88 |
| D | ILE89 |
| D | VAL177 |
| D | ASN178 |
| D | PHE212 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 500 |
| Chain | Residue |
| D | ARG404 |
| D | SER405 |
| D | ALA481 |
| D | ASP482 |
| D | SER400 |
| D | ASN401 |
| D | THR402 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K D 501 |
| Chain | Residue |
| D | ASN51 |
| D | SER53 |
| D | THR84 |
| D | LYS238 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE K D 502 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE QV7 D 503 |
| Chain | Residue |
| D | HIS54 |
| D | GLY55 |
| D | GLY55 |
| D | SER56 |
| D | SER56 |
| D | TYR59 |
| D | TYR59 |
| D | LYS335 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE QV7 A 499 |
| Chain | Residue |
| A | SER53 |
| A | HIS54 |
| A | GLY55 |
| A | LYS335 |
| A | HOH655 |
| B | ARG231 |
| B | ARG404 |
| B | ARG407 |
| B | QV7499 |
| B | QV8500 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 500 |
| Chain | Residue |
| A | SER400 |
| A | ASN401 |
| A | THR402 |
| A | GLY403 |
| A | ARG404 |
| A | SER405 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE K A 501 |
| Chain | Residue |
| A | GLU240 |
| A | ASP264 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K A 502 |
| Chain | Residue |
| A | GLN354 |
| A | LEU357 |
| A | GLU359 |
| site_id | BC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE QV7 B 499 |
| Chain | Residue |
| A | THR26 |
| A | PRO29 |
| A | ASN51 |
| A | HIS54 |
| A | GLY55 |
| A | SER56 |
| A | TYR59 |
| A | ALA334 |
| A | LYS335 |
| A | QV7499 |
| B | THR402 |
| B | ARG404 |
| B | ASP482 |
| B | HIS483 |
| B | LYS486 |
| B | HOH514 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE QV8 B 500 |
| Chain | Residue |
| A | QV7499 |
| B | ARG231 |
| B | ASP232 |
| B | THR402 |
| B | ARG424 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE QV7 B 501 |
| Chain | Residue |
| A | SER1 |
| B | SER1 |
| B | TYR360 |
| B | VAL361 |
| B | ASN364 |
| B | QV7504 |
| D | ASN364 |
| D | LYS368 |
| D | HOH507 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K B 503 |
| Chain | Residue |
| B | GLN354 |
| B | LEU357 |
| B | GLU359 |
| B | HOH575 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE QV7 B 504 |
| Chain | Residue |
| A | SER1 |
| A | TYR360 |
| A | VAL361 |
| A | ASN364 |
| B | SER1 |
| B | QV7501 |
| C | SER1 |
| C | VAL361 |
| C | LYS368 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 499 |
| Chain | Residue |
| C | SER400 |
| C | ASN401 |
| C | THR402 |
| C | ARG404 |
| C | SER405 |
| C | ALA481 |
| C | ASP482 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 500 |
| Chain | Residue |
| C | ASP83 |
| C | THR84 |
| C | LYS238 |
| C | HOH656 |
| C | ASN51 |
| C | SER53 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE K C 501 |
| Chain | Residue |
| C | GLN354 |
| C | LEU357 |
| C | GLU359 |
Functional Information from PROSITE/UniProt
| site_id | PS00110 |
| Number of Residues | 13 |
| Details | PYRUVATE_KINASE Pyruvate kinase active site signature. ImIICKIENhQGV |
| Chain | Residue | Details |
| D | ILE233-VAL245 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Transition state stabilizer"} |
3QV7
