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3QV7

Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with ponceau S and acid blue 25.

Summary for 3QV7
Entry DOI10.2210/pdb3qv7/pdb
Related1PKL 3QV6 3QV8 3QV9
DescriptorPyruvate kinase, SULFATE ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywordspyruvate kinase, glycolysis, tim barrel, sugar kinase, adp/atp binding, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceLeishmania mexicana
Total number of polymer chains4
Total formula weight222311.36
Authors
Morgan, H.P.,Auld, D.S.,McNae, I.W.,Nowicki, M.W.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (deposition date: 2011-02-25, release date: 2011-06-29, Last modification date: 2023-09-13)
Primary citationMorgan, H.P.,McNae, I.W.,Nowicki, M.W.,Zhong, W.,Michels, P.A.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.
The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.
J.Biol.Chem., 286:31232-31240, 2011
Cited by
PubMed: 21733839
DOI: 10.1074/jbc.M110.212613
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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