3PP7

Crystal structure of Leishmania mexicana pyruvate kinase in complex with the drug suramin, an inhibitor of glycolysis.

Summary for 3PP7

Entry DOI	10.2210/pdb3pp7/pdb
Related	3IS4
Descriptor	Pyruvate kinase, pyrene-1,3,6,8-tetrasulfonic acid, GLYCEROL, ... (6 entities in total)
Functional Keywords	tim barrel, glycolysis, adp/atp binding, cytosol, symmetric drug, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Leishmania mexicana
Total number of polymer chains	2
Total formula weight	110833.84
Authors	Morgan, H.P.,Auld, D.S.,McNae, I.W.,Nowicki, M.W.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (deposition date: 2010-11-24, release date: 2010-12-15, Last modification date: 2023-09-06)
Primary citation	Morgan, H.P.,McNae, I.W.,Nowicki, M.W.,Zhong, W.,Michels, P.A.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J.Biol.Chem., 286:31232-31240, 2011 Cited by PubMed: 21733839 DOI: 10.1074/jbc.M110.212613 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation