3HQP

Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK) in complex with ATP, Oxalate and fructose 2,6 bisphosphate

Summary for 3HQP

• Entry DOI: 10.2210/pdb3hqp/pdb
• Related: 1PKL 3E0V 3E0W 3HQN 3HQO 3HQQ
• Descriptor: Pyruvate kinase, MAGNESIUM ION, POTASSIUM ION, ... (8 entities in total)
• Functional Keywords: tim barrel, t-state enzyme, allosteric enzyme, glycolysis, kinase, magnesium, metal-binding, pyruvate, transferase
• Biological source: Leishmania mexicana
• Total number of polymer chains: 16
• Total formula weight: 888389.65

Authors

Morgan, H.P.,Walkinshaw, M.D. (deposition date: 2009-06-08, release date: 2010-02-16, Last modification date: 2023-11-01)

• Primary citation: Morgan, H.P.,McNae, I.W.,Nowicki, M.W.,Hannaert, V.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.; The allosteric mechanism of pryuvate kinase from Leishmania mexicana: a rock and lock model; J.Biol.Chem., 285:12892-12898, 2010; PubMed: 20123988; DOI: 10.1074/jbc.M109.079905

Experimental method

X-RAY DIFFRACTION (2.3 Å)