3HQP

Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK) in complex with ATP, Oxalate and fructose 2,6 bisphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005524	molecular_function	ATP binding
A	0006096	biological_process	glycolytic process
A	0006950	biological_process	response to stress
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030955	molecular_function	potassium ion binding
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004743	molecular_function	pyruvate kinase activity
B	0005524	molecular_function	ATP binding
B	0006096	biological_process	glycolytic process
B	0006950	biological_process	response to stress
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0030955	molecular_function	potassium ion binding
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004743	molecular_function	pyruvate kinase activity
C	0005524	molecular_function	ATP binding
C	0006096	biological_process	glycolytic process
C	0006950	biological_process	response to stress
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0030955	molecular_function	potassium ion binding
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005524	molecular_function	ATP binding
D	0006096	biological_process	glycolytic process
D	0006950	biological_process	response to stress
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0030955	molecular_function	potassium ion binding
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004743	molecular_function	pyruvate kinase activity
E	0005524	molecular_function	ATP binding
E	0006096	biological_process	glycolytic process
E	0006950	biological_process	response to stress
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0030955	molecular_function	potassium ion binding
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004743	molecular_function	pyruvate kinase activity
F	0005524	molecular_function	ATP binding
F	0006096	biological_process	glycolytic process
F	0006950	biological_process	response to stress
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0030955	molecular_function	potassium ion binding
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000287	molecular_function	magnesium ion binding
G	0003824	molecular_function	catalytic activity
G	0004743	molecular_function	pyruvate kinase activity
G	0005524	molecular_function	ATP binding
G	0006096	biological_process	glycolytic process
G	0006950	biological_process	response to stress
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0030955	molecular_function	potassium ion binding
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0000287	molecular_function	magnesium ion binding
H	0003824	molecular_function	catalytic activity
H	0004743	molecular_function	pyruvate kinase activity
H	0005524	molecular_function	ATP binding
H	0006096	biological_process	glycolytic process
H	0006950	biological_process	response to stress
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0030955	molecular_function	potassium ion binding
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0000287	molecular_function	magnesium ion binding
I	0003824	molecular_function	catalytic activity
I	0004743	molecular_function	pyruvate kinase activity
I	0005524	molecular_function	ATP binding
I	0006096	biological_process	glycolytic process
I	0006950	biological_process	response to stress
I	0016301	molecular_function	kinase activity
I	0016740	molecular_function	transferase activity
I	0030955	molecular_function	potassium ion binding
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0000287	molecular_function	magnesium ion binding
J	0003824	molecular_function	catalytic activity
J	0004743	molecular_function	pyruvate kinase activity
J	0005524	molecular_function	ATP binding
J	0006096	biological_process	glycolytic process
J	0006950	biological_process	response to stress
J	0016301	molecular_function	kinase activity
J	0016740	molecular_function	transferase activity
J	0030955	molecular_function	potassium ion binding
J	0046872	molecular_function	metal ion binding
K	0000166	molecular_function	nucleotide binding
K	0000287	molecular_function	magnesium ion binding
K	0003824	molecular_function	catalytic activity
K	0004743	molecular_function	pyruvate kinase activity
K	0005524	molecular_function	ATP binding
K	0006096	biological_process	glycolytic process
K	0006950	biological_process	response to stress
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0030955	molecular_function	potassium ion binding
K	0046872	molecular_function	metal ion binding
L	0000166	molecular_function	nucleotide binding
L	0000287	molecular_function	magnesium ion binding
L	0003824	molecular_function	catalytic activity
L	0004743	molecular_function	pyruvate kinase activity
L	0005524	molecular_function	ATP binding
L	0006096	biological_process	glycolytic process
L	0006950	biological_process	response to stress
L	0016301	molecular_function	kinase activity
L	0016740	molecular_function	transferase activity
L	0030955	molecular_function	potassium ion binding
L	0046872	molecular_function	metal ion binding
M	0000166	molecular_function	nucleotide binding
M	0000287	molecular_function	magnesium ion binding
M	0003824	molecular_function	catalytic activity
M	0004743	molecular_function	pyruvate kinase activity
M	0005524	molecular_function	ATP binding
M	0006096	biological_process	glycolytic process
M	0006950	biological_process	response to stress
M	0016301	molecular_function	kinase activity
M	0016740	molecular_function	transferase activity
M	0030955	molecular_function	potassium ion binding
M	0046872	molecular_function	metal ion binding
N	0000166	molecular_function	nucleotide binding
N	0000287	molecular_function	magnesium ion binding
N	0003824	molecular_function	catalytic activity
N	0004743	molecular_function	pyruvate kinase activity
N	0005524	molecular_function	ATP binding
N	0006096	biological_process	glycolytic process
N	0006950	biological_process	response to stress
N	0016301	molecular_function	kinase activity
N	0016740	molecular_function	transferase activity
N	0030955	molecular_function	potassium ion binding
N	0046872	molecular_function	metal ion binding
O	0000166	molecular_function	nucleotide binding
O	0000287	molecular_function	magnesium ion binding
O	0003824	molecular_function	catalytic activity
O	0004743	molecular_function	pyruvate kinase activity
O	0005524	molecular_function	ATP binding
O	0006096	biological_process	glycolytic process
O	0006950	biological_process	response to stress
O	0016301	molecular_function	kinase activity
O	0016740	molecular_function	transferase activity
O	0030955	molecular_function	potassium ion binding
O	0046872	molecular_function	metal ion binding
P	0000166	molecular_function	nucleotide binding
P	0000287	molecular_function	magnesium ion binding
P	0003824	molecular_function	catalytic activity
P	0004743	molecular_function	pyruvate kinase activity
P	0005524	molecular_function	ATP binding
P	0006096	biological_process	glycolytic process
P	0006950	biological_process	response to stress
P	0016301	molecular_function	kinase activity
P	0016740	molecular_function	transferase activity
P	0030955	molecular_function	potassium ion binding
P	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. ImIICKIENhQGV

Chain	Residue	Details
A	ILE233-VAL245

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ARG49
B	ARG49
L	ARG49
L	ASN51
L	SER53
L	ASP83
L	THR84
L	GLU240
L	GLY263
L	ASP264
L	THR296
M	ARG49
B	ASN51
M	ASN51
M	SER53
M	ASP83
M	THR84
M	GLU240
M	GLY263
M	ASP264
M	THR296
N	ARG49
N	ASN51
B	SER53
N	SER53
N	ASP83
N	THR84
N	GLU240
N	GLY263
N	ASP264
N	THR296
O	ARG49
O	ASN51
O	SER53
B	ASP83
O	ASP83
O	THR84
O	GLU240
O	GLY263
O	ASP264
O	THR296
P	ARG49
P	ASN51
P	SER53
P	ASP83
B	THR84
P	THR84
P	GLU240
P	GLY263
P	ASP264
P	THR296
B	GLU240
B	GLY263
B	ASP264
B	THR296
C	ARG49
A	ASN51
C	ASN51
C	SER53
C	ASP83
C	THR84
C	GLU240
C	GLY263
C	ASP264
C	THR296
D	ARG49
D	ASN51
A	SER53
D	SER53
D	ASP83
D	THR84
D	GLU240
D	GLY263
D	ASP264
D	THR296
E	ARG49
E	ASN51
E	SER53
A	ASP83
E	ASP83
E	THR84
E	GLU240
E	GLY263
E	ASP264
E	THR296
F	ARG49
F	ASN51
F	SER53
F	ASP83
A	THR84
F	THR84
F	GLU240
F	GLY263
F	ASP264
F	THR296
G	ARG49
G	ASN51
G	SER53
G	ASP83
G	THR84
A	GLU240
G	GLU240
G	GLY263
G	ASP264
G	THR296
H	ARG49
H	ASN51
H	SER53
H	ASP83
H	THR84
H	GLU240
A	GLY263
H	GLY263
H	ASP264
H	THR296
I	ARG49
I	ASN51
I	SER53
I	ASP83
I	THR84
I	GLU240
I	GLY263
A	ASP264
I	ASP264
I	THR296
J	ARG49
J	ASN51
J	SER53
J	ASP83
J	THR84
J	GLU240
J	GLY263
J	ASP264
A	THR296
J	THR296
K	ARG49
K	ASN51
K	SER53
K	ASP83
K	THR84
K	GLU240
K	GLY263
K	ASP264
K	THR296

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P14618

Chain	Residue	Details
A	ARG90
J	ARG90
K	ARG90
L	ARG90
M	ARG90
N	ARG90
O	ARG90
P	ARG90
B	ARG90
C	ARG90
D	ARG90
E	ARG90
F	ARG90
G	ARG90
H	ARG90
I	ARG90

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	LYS238
J	LYS238
K	LYS238
L	LYS238
M	LYS238
N	LYS238
O	LYS238
P	LYS238
B	LYS238
C	LYS238
D	LYS238
E	LYS238
F	LYS238
G	LYS238
H	LYS238
I	LYS238

---