3QV8

Crystal structure of Leishmania mexicana pyruvate kinase(LmPYK)in complex with benzothiazole-2,5-disulfonic acid.

Summary for 3QV8

Entry DOI	10.2210/pdb3qv8/pdb
Related	1PKL 3QV6 3QV7 3QV9
Descriptor	Pyruvate kinase, 1,3-benzothiazole-2,5-disulfonic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	pyruvate kinase, glycolysis, tim barrel, sugar kinase, adp/atp binding, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Leishmania mexicana
Total number of polymer chains	2
Total formula weight	109906.38
Authors	Morgan, H.P.,Auld, D.S.,McNae, I.W.,Nowicki, M.W.,Michels, P.A.M.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. (deposition date: 2011-02-25, release date: 2011-06-29, Last modification date: 2023-09-13)
Primary citation	Morgan, H.P.,McNae, I.W.,Nowicki, M.W.,Zhong, W.,Michels, P.A.,Auld, D.S.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D. The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site. J.Biol.Chem., 286:31232-31240, 2011 Cited by PubMed: 21733839 DOI: 10.1074/jbc.M110.212613 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation